CAS: 60421-23-0; Methyl 1-Aminocyclopentanecarboxylate Hydrochloride

该化合物是化学化合物,其结构特征为循环开关环,由氨基氨基化合物和碳酸盐混合物替代,该化合物一般是白色到白外晶状固体,在水和各种有机溶剂中溶解,反映其极性,因为氨基和碳化甲酸的功能组的存在,盐酸形式表明它是盐酸形成的盐,可以提高其稳定性和溶性.Mephy 1-氨基-1-环开丙烷丙烯酸盐可展示生物活动,使其对制药研究感兴趣,特别是针对特定受体或路径的药物研发具有兴趣.其合成涉及标准的有机反应,可使用NMR光谱分析,质量光谱测量和红外线光谱学等技术确定其结构和纯度.与所有化学物质一样,由于潜在的毒性或再活性,应观察适当的处理和安全防范措施.

英文名称Methyl 1-Aminocyclopentanecarboxylate Hydrochloride
中文名称1-氨基环戊烷甲酸甲酯盐酸盐
IUPAC名称methyl 1-aminocyclopentane-1-carboxylate hydrochloride
其它别名环亮氨酸甲酯盐酸盐; Methyl1-Aminocyclopentanecarboxylatehcl(Cycloleucinemethylesterhcl)
CAS编号60421-23-0
MFCD编号:MFCD03840364
EINECS号:820-764-6
分子式:C7H14ClNO2
分子量:179.64
产品CID: 1580462
产品分类有机原料→生命科学→氨基酸及其衍生物→C-保护氨基酸

相似结构搜索
InChIKey: OPUJUITUYWGUEP-UHFFFAOYSA-N
InChI=1S/C7H13NO2/c1-10-6(9)7(8)4-2-3-5-7/h2-5,8H2,1H3…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

78388-61-1 52-52-8 10316-79-7

物理性质

熔点207-208 °C
沸点272.3±23.0 °C at 760 mmHg
闪点58.7°C
密度1.081
PSA:52.32
LogP:0.8527
折射率1.478
外观形态白色至几乎白色粉末至晶体
储存条件惰性气氛,室温
产品应用该化合物用作合成HBV聚合酶抑制剂,1型11Β-羟基类脱氢酶(11Β/HSD1)抑制剂,G蛋白共振受体调节器和CB1敌体的药物中间体.

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

欧盟法规

C&L通报

合成工艺路线路线简述

合成目标产物 Methyl 1-Amino-1-Cyclopentanecarboxylate Hydrochloride 主要起始原料 Methanol And Cycloleucine
(文献来源)合成步骤主要原料 Methanol 和 Cycloleucine

环亮氨酸以甲醇作为反应溶剂,化学反应生成环亮氨酸甲酯盐酸盐
参考文献:Certain Thiol Inhibitors Of Endothelin-Converting Enzyme
标题:Certain Thiol Inhibitors Of Endothelin-Converting Enzyme
摘要:披露的内皮素转化酶抑制剂是具有以下公式的化合物,其中变量的含义如前文所定义.

海关参考信息

2905121000-正丙醇
2912110000-甲醛
2912120000-乙醛
2915110000-甲酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2006167268-A1
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.