CAS: 67490-21-5; 2,4,6-Tri-Tertbutylpyrimidine

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127958-18-3 1426088-89-2 67490-17-9

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CAS号75-97-8 频那酮 | CAS号630-18-2 三甲基乙腈 | CAS号917-92-0 3,3-二甲基-1-丁炔 | CAS号27701-32-2 3,3-dimethyl-2-... | CAS号69050-89-1 2,4-ditert-buty... | CAS号594-19-4 叔丁基锂 | CAS号128939-59-3 2,4-di-t-butyl-...

2,4-Di-Tert-Butyl-6-Chloropyrimidine置于氢碘酸,Copper(L) Cyanide体系中,化学反应 0.25H,反应生成 2,4,6-三叔丁基嘧啶
参考文献:The Synthesis Of 4(6)-T-Butylpyrimidines From 4(6)-Halopyrimidines By Using Higher-Order Lithium And Magnesium Organocuprate Reagents
标题:The Synthesis Of 4(6)-T-Butylpyrimidines From 4(6)-Halopyrimidines By Using Higher-Order Lithium And Magnesium Organocuprate Reagents
摘要:用 T-丁基锂和 T-丁基氯化镁氰基杯酸盐从相应的 4(6)-卤代嘧啶制备 4(6)-T-丁基嘧啶.用这种方法制备了高度受阻的 2,4,5-三丁基-6-氯嘧啶,其中含有正交二叔丁基排列.没有观测到烷基异构化现象,但发现了一些底物还原现象.
DOI:10.1071/ch9900733

专利信息

专利号:US-9938312-B2
优先权日:2011-03-25
标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans
发明人：BOONS GEERT-JAN; WANG ZHEN
权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA
摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.

专利号:US-11306157-B2
优先权日:2018-12-21
标 题:Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly
发明人：HSIEH-WILSON LINDA C; PAWAR NITIN J; WANG LEI
权利人:CALIFORNIA INST OF TECHN
摘要:Methods for the preparation of oligosaccharide products from polysaccharide starting materials are disclosed. The methods include: hydrolyzing a glucosamine-containing polysaccharide starting material, such as heparin or heparosan, under conditions sufficient to form an oligosaccharide intermediate (e.g., a GlcN-IdoA disaccharide intermediate or a GlcA-GlcN disaccharide intermediate), and converting the oligosaccharide intermediate to the oligosaccharide product. Conversion of the oligosaccharide intermediates to the oligosaccharide products may include one or more esterification, acylation, epimerization, protection, and deprotection steps. Preparation of higher-order oligomers is described, as well as methods for selective oligosaccharide sulfation.

专利号:US-2024209029-A1
优先权日:2021-04-21
标题:Adiponectin glycopeptides and compositions and methods of use thereof
发明人：WANG YU; LI XUECHEN; XU AIMIN; WU HONGXIANG; ZHANG YIWEI; LI YUANXIN
权利人:UNIV HONG KONG
摘要:An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.

专利号:US-6930187-B2
优先权日:2002-02-15
标题:Method of preparation of 21-amino epothilone derivatives
发明人：FAVREAU DENIS; KANT JOYDEEP; LEVESQUE KATHIA; WANG SHAOPENG; GUO ZHENGRONG; JAMES BRIAN LESLIE
权利人:BRISTOL MYERS SQUIBB CO
摘要:An improved method of synthesis of 21-amino epothilone derivatives which provides a one-pot conversion of 21-hydroxy epothilones to highly desirable 21-amino epothilones in high yield.

专利号:US-6960654-B2
优先权日:2002-06-11
标题 :Method of forming glycosidic bonds from thioglycosides using an N,N-dialkylsulfinamide
发明人：CRICH DAVID C; SMITH MARK
权利人:UNIV ILLINOIS
摘要:A method of forming a glycosidic bond utilizing an activated thioglycoside is disclosed. The thioglycoside is activated by an N,N-dialkylsulfinamide and trifluoromethanesulfonic anhydride. The method allows the facile synthesis of disaccharides, oligosacchraides, and polysaccharides in solution or on a polymer support.

专利号:US-2025282810-A1
优先权日:2024-06-19
标题 :Chemical Synthesis Method and Application of V. Cholerae Serotype O100 O-Antigen Oligosaccharides
发明人：YIN JIAN; HU JING; CHEN GUODONG
权利人:UNIV JIANGNAN
摘要:The disclosure discloses a chemical synthesis method and an application of V. cholerae serotype O100 O-antigen oligosaccharides, belonging to the field of chemical technologies. The disclosure uses three monosaccharide building blocks and five carboxylic acid derivatives to synthesize five oligosaccharide fragments of V. cholerae serotype O100 O-antigen under the action of the solvent effect, temperature effect, neighboring group participation effect, etc., through orthogonal protection, selective assembly and amide coupling. The absolute configurations and immunological effects of 3,5-dihydroxyhexanoyl in the O-antigen trisaccharide are illustrated by the synthesized oligosaccharide fragments in combination with the NMR analysis and glycan microarray technology, thereby providing a theoretical basis for further structure-activity study and minimal antigenic epitope screening. The disclosure has excellent application prospects in the aspects of development of V. cholerae synthetic glycoconjugate vaccines and new drugs, etc.