CAS: 1256589-74-8; 9-Ethyl-6,6-Dimethyl-8-(4-Morpholin-4-Ylpiperidin-1-yl)-11-Oxo-5H-Benzo[b]Carbazole-3-Carbonitrile,Hydrochloride

上下游产品

CAS号1256580-46-7 艾乐替尼

艾乐替尼置于盐酸,甲烷,溶剂黄146体系中,用 甲醇,水,丁酮 用作溶剂,化学反应 1.0H,以84.38%的收率获得艾乐替尼盐酸盐
参考文献: A Novel Process For The Preparation Of An Intermediate Of Alectinib[fr] Nouveau Procédé De Préparation D'Un Intermédiaire D'Alectinib
标题: A Novel Process For The Preparation Of An Intermediate Of Alectinib[fr] Nouveau Procédé De Préparation D'Un Intermédiaire D'Alectinib
摘要:本发明提供了一种制备2-(4-乙基-3-碘苯基)-2-甲基丙酸的新型方法,该化合物为公式(I)中的关键中间体,公式(I)是合成alectinib或其盐的关键中间体.

专利信息

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-2024262829-A1
优先权日:2021-04-21
标 题:Peptide nucleic acids, synthesis, and uses thereof
发明人：ROTHMAN JEFFREY
权利人:ONCOGENUITY INC
摘要:The present disclosure provides peptide nucleic acids (PNAs) including cyclic structural moieties such as tetrahydrofuran, pyrrolidinium, pyrrolidine, or N-methyl pyrrolidine, which have surprisingly improved the water solubility and binding affinity of PNA oligomers to ribose-phosphate nucleic acid oligomers. Pharmaceutical compositions including the disclosed PNAs, synthetic methods thereof, and methods of use thereof are also disclosed.

专利号:CN-116490201-A
优先权日:2020-07-02
标题 :Inhibitors of YAP/TAZ-TEAD tumor proteins, their synthesis and use

专利号:EP-4175658-A1
优先权日:2020-07-02
标题 :Inhibitors of yap/taz-tead oncoproteins, synthesis and use thereof

专利号:US-2023286904-A1
优先权日:2020-07-02
标 题 :Inhibitors of yap/taz-tead oncoproteins, synthesis and use thereof