专利号:US-5759942-A 优先权日:1994-10-25 标 题:Ion exchange resin catalyst for the synthesis of bisphenols and the process for preparing the same 发明人:TAN QIU; JIN ZUQUAN; JIANG HONGSHOU; LIU ZONGZHANG; HE BINGJUN 权利人:CHINA PETROCHEMICAL CORP; UNIV TIANJIN 摘要:An ion exchange resin catalyst containing sulfonated styrene-divinylbenzene copolymer, a porous structure with micropore area and transfer pass networks, the transfer pass network is composed of main pass networks and branch pass networks, in non-swollen state, the pore size of the main pass network is 9x103-38x103 nanometer and the pore size of the branch pass network is 20-150 manometer, the pore size of the micropore area pass is 5-20 nanometer, wherein the pore capacity of the micropore pass with the pore size of 5-10.4 nm is more than 50% of the total pore capacity of the micropore area, and the ratio of the pore capacity of the micropore area to that of the transfer network area is 0.25-1.1. The catalyst is useful to condense phenols with ketones.
专利号:WO-2005030747-A1 优先权日:2003-09-29 标 题:A process for the synthesis of 3-hydroxy-gamma-butyrolactone 发明人:SHIN HYUN-IK; CHANG JAY-HYOK; WOO YOUNG-MIN; KIM YOUNG-SOOK 权利人:LG LIFE SCIENCES LTD; SHIN HYUN-IK; CHANG JAY-HYOK; WOO YOUNG-MIN; KIM YOUNG-SOOK 摘要:The present invention relates to a process for preparing pure 3-hydroxy-Ïœ-butyrolactone by hydrolyzing 4-chloro-3-hydroxy-butyronitrile in the presence of acids and conducting cyclization reaction under slightly basic condition.
专利号:US-10633315-B2 优先权日:2016-10-19 标 题:Synthesis of bicyclo[2.2.2]octanes 发明人:HU YUE RACHEL; HEMBRE ROBERT THOMAS; TUSTIN GERALD CHARLES; BURK CHRISTOPHER HARLAN 权利人:EASTMAN CHEM CO 摘要:Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst comprising a palladium compound to afford certain oxo-substituted bicyclo[2.2.2]octane species. The process of the invention thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
专利号:EP-3529230-B1 优先权日:2016-10-19 标 题 :Synthesis of bicyclo(2.2.2)octanes
专利号:EP-3119796-A1 优先权日:2014-03-16 标题:Synthesis of bicyclic nucleosides
专利号:EP-1025077-B1 优先权日:1997-10-15 标题 :Novel aryloxy-alkyl-dialkylamines 发明人:RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN RICHARD; REN JIANXIN 权利人:WYETH CORP 摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having formula (I) wherein: R?1 and R2¿ are, independently, selected from H; C¿1?-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R?3, R4, R5, and R6¿ are independently selected from H, halogen, -NO¿2?, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R?1¿, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO¿2?-R?1, -SO¿2-Ar, -CO-R1, -CO-Ar, -CO¿2-R?1, or -CO¿2?-Ar; and Y is selected from a) the moiety (i) wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.
1: Wang L, Liu S, Liang W, Li D, Yang J, He Y. Detection of DNA utilizing a fluorescent reversible change of a biosensor based on the electron transfer from quantum dots to polymyxin B sulfate. J Colloid Interface Sci. 2015 Jun 15;448:257-64. doi: 10.1016/j.jcis.2015.02.034. Epub 2015 Feb 23. doi: 10.1002/bio.2471. Epub 2013 Jan 9. doi: 10.2146/ajhp090472. Chinese. Hungarian. 12: Issekutz AC, Biggar WD. Effect of methylprednisolone and polymyxin B sulfate on endotoxin-induced inhibition of human neutrophil chemotaxis. J Lab Clin Med. 1978 Dec;92(6):873-82. Russian. Japanese.