CAS: 2826-26-8; 2-(4-Methoxybenzylidene)Malononitrile
该化合物是抑制上皮瘤生长因子受体(EGFR)强力抗体的选择性抑制剂,广泛用于生化和药理研究,其主要优势在于它能够通过竞争抑制与EGFR的基质抗体结合的ATP,从而阻断细胞扩散和生存的下游信号路径.Tyophostin A1对EGFR具有高度的特殊性,与更广泛的活性酶抑制剂相比,最大限度地减少目标外影响.这一化合物在探索EGFR的中间细胞过程的研究中特别有价值,包括诱导和信号传输.其精密的机制和一致的抑制性活动使得它成为试管和细胞研究应用的可靠工具.
- 英文名称2-(4-Methoxybenzylidene)Malononitrile
- 中文名称(4-甲氧基苄烯)丙二腈
- IUPAC名称2-(4-methoxybenzylidene)malononitrile
- 其它别名Malononitrile,(p-methoxybenzylidene)- (6CI,7CI,8CI); Propanedinitrile,[(4-methoxyphenyl)methylene]- (9CI); (4-Anisylidene)malonitrile; (4-Methoxybenzylidene)malononitrile; (p-Methoxybenzal)malononitrile; (p-Methoxybenzylidene)malononitrile; 1,1-Dicyano-2-(4-methoxyphenyl)ethene; 1-(2,2-Dicyanoethenyl)-4-methoxybenzene; 2-(4-Methoxybenzylidene)malononitrile; 2-Cyano-3-(p-methoxyphenyl)acrylonitrile; 2-[(4-Methoxyphenyl)methylene]malononitrile; 4-Methoxybenzylidenemalonodinitrile; AG 9; AG 9 (enzyme inhibitor); Tyrphostin 1; Tyrphostin A 1; [(4-Methoxyphenyl)methylene]propanedinitrile; a-Cyano-p-methoxycinnamonitrile
- CAS编号2826-26-8
- MFCD编号:MFCD00019787
- EINECS号:808-183-6
- 分子式:C11H8N2O
- 分子量:184.2
- 产品CID: 1262724
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号109-77-3 丙二腈 | CAS号3585-93-1 (4-甲氧基亚苄基)苯胺硝酮 | CAS号15795-54-7 5-[(4-METHOXYPH... | CAS号1885-23-0 2,2-二溴丙二腈 | CAS号670-54-2 四氰基乙烯 | CAS号14674-38-5 N-(4-甲氧基亚苄基)-4-... | CAS号105202-53-7 3-(4-methoxyphe... | CAS号4464-76-0 1,2-bis(4-metho... | CAS号123-38-6 丙醛 | CAS号5553-92-4 2-(4-甲氧基苄基)丙二腈 | CAS号1149-24-2 2,6-二甲基吡啶-3,5-二甲酸二乙酯 | CAS号2620-81-7 2-(4-甲氧基苯基)-1H-苯并咪唑 | CAS号23767-72-8 1,1,2,2-Cyclopr... | CAS号102423-74-5 2,6-diamino-4-(... | CAS号105263-07-8 5-acetyl-2-amin... | CAS号104-93-8 4-甲基苯甲醚(MSO) | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯...合成工艺路线路线简述
- 123-11-5 = 2826-26-8 + 868-54-2
反应条件:1.1 Catalysts: Potassium Hydroxide; 1 H,Rt
标题:A Simple And Efficient Method For The Facile Access Of Highly Functionalized Pyridines And Their Fluorescence Property Studies
作者:Khan,Nasim Md.; Et Al
参考文献:Rsc Advances 日期:2012 卷标:2(32) 页码:12305-12314
在 N-甲基吖啶体系中,用 乙腈 用作溶剂,化学反应生成(4-甲氧基苄烯)丙二腈
参考文献:一种简便的实验方法,用于确定极化烯烃在乙腈中的氢化物亲和力.
标题:一种简便的实验方法,用于确定极化烯烃在乙腈中的氢化物亲和力.
摘要:
Doi:10.1002/anie.200600536
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2902500000-苯乙烯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2014073003-A1
优先权日:2012-11-09
标题:Single-step process for the preparation of aryl olefins
发明人：BORATE HANUMANT BAPURAO; GAIKWAD SUPRIYA HANUMANT; KUDALE ANANDA SHAHAJI; CHAVAN SUBHASH PRATAPRAO; PHARANDE SHRIKANT GANPAT; WAGH VITTHAL DATTATRAYA; SAWANT VIKRAM SHAHAJI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to the single-step process for the synthesis of aryl olefin compounds of Formula (1) by reacting aryl aldehydes with alkyl aldehydes in presence of malononitrile and acid or base or salt, optionally in presence of solvent.
专利号:CN-102924202-A
优先权日:2012-11-15
标题:Solvent-free and heat-free synthesis of benzylidene malononitrile and its derivatives
专利号:US-7052692-B1
优先权日:1997-09-02
标题:Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
发明人：SRIVASTAVA ARUN; QING KEYUN; WANG XU-SHAN; PONNAZHAGAN SELVARANGAN; BAJPAI ANIL
权利人:ADVANCED RES & TECH INST
摘要:The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed herein.
专利号:CN-103804268-A
优先权日:2013-12-29
标 题:An Efficient Synthesis of Functionalized Enamines with High Regioselectivity
专利号:CN-103804268-B
优先权日:2013-12-29
标 题:An Efficient Synthesis of Functionalized Enamines with High Regioselectivity
专利号:CN-110092734-B
优先权日:2019-05-22
标 题 :A kind of tandem synthesis method of 2-(phenylmethylene) malononitrile or its derivative
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主要参考文献
1: Corrêa Gde R, Cunha KC, dos Santos AA, de Araujo EG. The trophic effect of ouabain on retinal ganglion cell is mediated by EGF receptor and PKC delta activation. Neurochem Res. 2010 Sep;35(9):1343-52. doi: 10.1007/s11064-010-0190-7. Epub 2010 May 25. doi: 10.1002/cmdc.200900054. Epub 2005 Jun 15.
7: Tsukagoshi H, Kawata T, Shimizu Y, Ishizuka T, Dobashi K, Mori M. 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway. Toxicol Appl Pharmacol. 2002 Nov 1;184(3):127-35. Chinese.
合成参考文献
摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 99.
摘要:Mase, N., Science of Synthesis Knowledge Updates, (2013) 3, 437.
摘要:Stoltz, B. M.; Mohr, J. T., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 647.
摘要:Fan, Y. C.; Kwon, O., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 741.
摘要:Fan, Y. C.; Kwon, O., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 744.
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