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CAS号1121-79-5 3-氯-6-甲基哒嗪 | CAS号72093-07-3 5-氯-2-甲基吡啶 | CAS号65202-58-6 3-溴-6-甲基哒嗪 | CAS号18591-78-1 6-甲基-[1,2,4]噻唑并...5-氯-3-甲基吡啶置于肼体系中,用 乙醇 作为反应溶剂,化学反应 2.5H,以81%的收率获得产物3-肼基-6-甲基哒嗪
参考文献:Ep1785418
标题:Ep1785418
专利信息
专利号:US-6794512-B2
优先权日:2001-11-02
标 题:Efficient synthesis of 5-heteroatom-containing -pyrazoles
发明人:SHAVNYA ANDREI; SAYKA SUBAS M; MINICH MARTHA L; RAST BRYSON
权利人:PFIZER
摘要:An efficient synthesis of sulfonyl pyrazoles of formula I: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, R 1 through R 9 are as defined in the specification, comprising reacting a compound of formula II: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m R 1 through R 9 are as defined above and wherein R 10 is halo, (C 1 -C 6 )alkyl-SO 3 —, (C 6 -C 10 )aryl-SO 3 —, (C 1 -C 6 )alkyl-SO 2 —, or (C 6 -C 10 )aryl-SO 2 —; wherein each of said (C 1 -C 6 )alkyl component of said (C 1 -C 6 )alkyl-SO 3 — and (C 1 -C 6 )alkyl-SO 2 — radicals may optionally be substituted on any carbon atom by one to six fluoro substituents per (C 1 -C 6 )alkyl component; with a compound of formula R 3 —H, wherein R 3 is as defined above, in the presence of a fluoride containing salt and in the presence of a solvent.
专利号:US-2003139407-A1
优先权日:2001-11-02
标 题 :Efficient synthesis of 5-heteroatom-containing -pyrazoles
专利号:US-2004210052-A1
优先权日:2001-11-02
标题:Efficient synthesis of 5-heteroatom-containing-pyrazoles
专利号:CN-114540846-B
优先权日:2022-02-10
标题:Synthesis method of 1,2, 4-triazolo six-membered nitrogen heterocycle-3-amine