CAS: 5976-47-6; 2-Chloro-2-Propen-1-Ol

该化合物是一种有机化合物,其特点是不饱和酒精功能组和氯原子的存在;C3H5ClO分子配方,其第一和第二碳原子之间具有双重联系,有助于其再活性;该化合物一般是无色的,可粉色黄色液体,有独特的味;在乙醇和乙醚等有机溶剂中溶解,但水溶性有限,因为其具有疏水性. 2-Chroloo-2-propen-1-ol因其在有机合成中使用而闻名,特别是在准备各种化学中间体和作为聚合反应中的试剂时;其活性受酒精和氯化合物的存在的影响,使其成为合成有机化学中一种有价值的化合物.然而,在处理该物质时,应谨慎行事,因为它可能构成健康风险,包括皮肤和呼吸系统受到刺激.

结构式图片

相似化合物

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合成工艺路线路线简述

    1,2,3-三氯丙烷置于sodium Carbonate体系中,化学反应生成 2-氯-2-丙烯-1-醇
    参考文献:Preparation Of 2-Chloroallyl Compounds
    标题:Preparation Of 2-Chloroallyl Compounds

    海关参考信息

    专利信息


    专利号:US-4769451-A
    优先权日:1985-08-15
    标 题:Synthesis of carbapenems using n-substituted azetidinones
    发明人:DEXTRAZE PIERRE
    权利人:BRISTOL MYERS CO
    摘要:A novel process is disclosed for converting known 3,4-disubstituted azetidinones to carbapenems. The process proceeds through novel N-substituted intermediates and then cyclizes to the 4-position of the azetidinone to form the carbapenem.

    专利号:US-4973687-A
    优先权日:1985-08-15
    标 题:Synthesis of carbapenems using N-substituted azetidinones
    发明人:DEXTRAZE PIERRE
    权利人:BRISTOL MYERS CO
    摘要:This invention provides novel azetidinone intermediates having the formulas: ##STR1## wherein R 1 is hydrogen, or a conventional hydroxy-protecting groups; R 2 , R 4 , and R 5 are independently selected from the group consisting of hydrogen; substituted and unsubstituted: alkyl, alkenyl, and alkynyl having from 1-10 carbon atoms; cycloalkyl, cycloalkylalkyl, and alkylcycloalkyl having 3-6 carbon atoms in the cycloalkyl ring and 1-6 carbon atoms in the alkyl moieties; spirocycloalkyl having 3-6 carbon atoms; phenyl; aralkyl, aralkenyl, and aralkynyl wherein the aryl moiety is phenyl and the aliphatic portion has 1-6 carbon atoms; or various heterocyclic moieties; and R 6 is methanesulfonyl or p-toluenesulfonyl; which are useful in the preparation of carbapenem antibiotics.

    专利号:US-5637757-A
    优先权日:1995-04-11
    标 题 :One-pot synthesis of ring-brominated benzoate compounds
    发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
    权利人:GREAT LAKES CHEMICAL CORP
    摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

    专利号:US-4119642-A
    优先权日:1975-09-24
    标 题:Butenolide synthesis via carbonylation of vinylmercurials in the presence of inorganic salts
    发明人:LAROCK RICHARD CRAIG
    权利人:UNIV IOWA STATE RES FOUND INC
    摘要:Compounds containing the butenolide ring have a wide variety of chemical uses. The invention is an improved method of synthesizing β-halobutenolides which are valuable intermediates in preparing a variety of butenolide ring containing compounds. The method comprises reacting an acetylenic alcohol with a mercuric halide to provide a vinylmercuric halide and carbonylating the vinylmercuric halide in the presence of a basic inorganic salt to provide a β-halobutenolide.

    专利号:WO-9632368-A1
    优先权日:1995-04-11
    标题:One-pot synthesis of ring-brominated benzoate compounds

    专利号:US-3383427-A
    优先权日:1962-12-17
    标题:Procedure for synthesis of propargyl alcohol
    发明人:WOLFE DONALD H
    权利人:DOW CHEMICAL CO
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    主要参考文献

    [参考文献]: Arjun S Raman, Et Al. Photofragment Imaging Study Of The Ch2Cch2Oh Radical Intermediate Of The Oh+allene Reaction. J Chem Phys. 2007 Oct 21;127(15):154316.
    [参考文献]: Ran Zhu, Et Al. Asymmetric Synthesis Of Conformationally Constrained Fingolimod Analogues--Discovery Of An Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist And Receptor Type-3 Antagonist. J Med Chem. 2007 Dec 13;50(25):6428-35.

    合成参考文献


    摘要:Haufe, G., Science of Synthesis Knowledge Updates, (2019) 3, 182.
    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#02539
    摘要:Shell Chemical Company. Unpublished Report., -(2), 1961
    摘要:Cui, H.; An, B.; Zhang, X., Science of Synthesis: Dearomatizations, (2026) .
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