专利号:US-4769451-A 优先权日:1985-08-15 标 题:Synthesis of carbapenems using n-substituted azetidinones 发明人:DEXTRAZE PIERRE 权利人:BRISTOL MYERS CO 摘要:A novel process is disclosed for converting known 3,4-disubstituted azetidinones to carbapenems. The process proceeds through novel N-substituted intermediates and then cyclizes to the 4-position of the azetidinone to form the carbapenem.
专利号:US-4973687-A 优先权日:1985-08-15 标 题:Synthesis of carbapenems using N-substituted azetidinones 发明人:DEXTRAZE PIERRE 权利人:BRISTOL MYERS CO 摘要:This invention provides novel azetidinone intermediates having the formulas: ##STR1## wherein R 1 is hydrogen, or a conventional hydroxy-protecting groups; R 2 , R 4 , and R 5 are independently selected from the group consisting of hydrogen; substituted and unsubstituted: alkyl, alkenyl, and alkynyl having from 1-10 carbon atoms; cycloalkyl, cycloalkylalkyl, and alkylcycloalkyl having 3-6 carbon atoms in the cycloalkyl ring and 1-6 carbon atoms in the alkyl moieties; spirocycloalkyl having 3-6 carbon atoms; phenyl; aralkyl, aralkenyl, and aralkynyl wherein the aryl moiety is phenyl and the aliphatic portion has 1-6 carbon atoms; or various heterocyclic moieties; and R 6 is methanesulfonyl or p-toluenesulfonyl; which are useful in the preparation of carbapenem antibiotics.
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-4119642-A 优先权日:1975-09-24 标 题:Butenolide synthesis via carbonylation of vinylmercurials in the presence of inorganic salts 发明人:LAROCK RICHARD CRAIG 权利人:UNIV IOWA STATE RES FOUND INC 摘要:Compounds containing the butenolide ring have a wide variety of chemical uses. The invention is an improved method of synthesizing β-halobutenolides which are valuable intermediates in preparing a variety of butenolide ring containing compounds. The method comprises reacting an acetylenic alcohol with a mercuric halide to provide a vinylmercuric halide and carbonylating the vinylmercuric halide in the presence of a basic inorganic salt to provide a β-halobutenolide.
专利号:WO-9632368-A1 优先权日:1995-04-11 标题:One-pot synthesis of ring-brominated benzoate compounds
专利号:US-3383427-A 优先权日:1962-12-17 标题:Procedure for synthesis of propargyl alcohol 发明人:WOLFE DONALD H 权利人:DOW CHEMICAL CO
[参考文献]: Arjun S Raman, Et Al. Photofragment Imaging Study Of The Ch2Cch2Oh Radical Intermediate Of The Oh+allene Reaction. J Chem Phys. 2007 Oct 21;127(15):154316. [参考文献]: Ran Zhu, Et Al. Asymmetric Synthesis Of Conformationally Constrained Fingolimod Analogues--Discovery Of An Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist And Receptor Type-3 Antagonist. J Med Chem. 2007 Dec 13;50(25):6428-35.
合成参考文献
摘要:Haufe, G., Science of Synthesis Knowledge Updates, (2019) 3, 182. 摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#02539 摘要:Shell Chemical Company. Unpublished Report., -(2), 1961 摘要:Cui, H.; An, B.; Zhang, X., Science of Synthesis: Dearomatizations, (2026) .