CAS: 92051-23-5; (2S,3S,4S,5R,6R)-6-(Acetoxymethyl)-3-(((Trifluoromethyl)Sulfonyl)Oxy)Tetrahydro-2H-Pyran-2,4,5-Triyl Triacetate

上下游产品

trifluoromethylsulfonic anhydride 1,3,4,6-tetra-O-acetyl-β-D-mannopyranose D-Mannose pentaacetate 3,4,6-tri-O-acetyl-1,2-O-(1-ethoxyethylidene)-β-D-mannopyranoside

1,3,4,6-四-氧-乙酰-β-D-吡啶甘露糖置于吡啶,Trifluoromethanesulfonic Acid Anhydride体系中,用 二氯甲烷 作为反应溶剂,以1.59 G (77%)的收率获得产物甘露糖三氟磺酸酯
参考文献:Sulfinyl Hexose Derivatives Useful For Glycosylation
标题:Sulfinyl Hexose Derivatives Useful For Glycosylation
摘要:描述了一种帮助控制固相糖基化反应过程中形成的糖苷键立体化学的己糖衍生物.还描述了它们的使用方法.

专利信息

专利号:US-7829032-B2
优先权日:2007-01-23
标题 :Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
发明人：VAN DAM ROBERT MICHAEL; BALL CARROLL EDWARD; ELIZAROV ARKADIJ M; KOLB HARTMUTH C
权利人:SIEMENS MEDICAL SOLUTIONS
摘要:The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.

专利号:US-8333952-B2
优先权日:2009-09-23
标 题:Dose synthesis module for biomarker generator system
发明人：NUTT RONALD; GIAMIS ANTHONY M; MCFARLAND AARON
权利人:NUTT RONALD; GIAMIS ANTHONY M; MCFARLAND AARON; ABT MOLECULAR IMAGING INC
摘要:A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, one (1) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The radiopharmaceutical production system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is purified by passing the solution through a solid phase extraction column and a filter. The synthesis process produces per run a quantity of radiopharmaceutical approximately equal to, but not less than, one (1) unit dose of a radiopharmaceutical, reducing waste and allowing for the production of radiopharmaceutical on an as-needed basis. The synthesis process allows for the production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between the synthesis of the radiopharmaceutical and the administration of that radiopharmaceutical, thereby minimizing the loss of active isotopes through decay and allowing the production of lesser amounts of radioisotopes overall.

专利号:US-10109385-B2
优先权日:2009-09-23
标题:Dose synthesis card for use with automated biomarker production system
发明人：MCFARLAND AARON; ANZELLOTTI ATILIO; HILLESHEIM DANIEL; BROWN-PROCTOR CLIVE; KHACHATURIAN MARK HAIG; LAND ANDREW
权利人:ABT MOLECULAR IMAGING INC
摘要:Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall.

专利号:US-8273300-B2
优先权日:2009-07-09
标题 :Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
发明人：ELIZAROV ARKADIJ M; BALL CARROLL EDWARD; ZHANG JIANZHONG; KOLB HARTMUTH C; MIRAGHAIE REZA; GRAVES TODD; LEBEDEV ARTEM
权利人:ELIZAROV ARKADIJ M; BALL CARROLL EDWARD; ZHANG JIANZHONG; KOLB HARTMUTH C; MIRAGHAIE REZA; GRAVES TODD; LEBEDEV ARTEM; SIEMENS MEDICAL SOLUTIONS
摘要:Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

专利号:US-8435454-B2
优先权日:2009-07-09
标 题:Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
发明人：ELIZAROV ARKADIJ M; BALL CARROLL EDWARD; ZHANG JIANZHONG; KOLB HARTMUTH C; MIRAGHAIE REZA; GRAVES TODD L; LEBEDEV ARTEM; SCHLEIFFER KEITH E
权利人:ELIZAROV ARKADIJ M; BALL CARROLL EDWARD; ZHANG JIANZHONG; KOLB HARTMUTH C; MIRAGHAIE REZA; GRAVES TODD L; LEBEDEV ARTEM; SCHLEIFFER KEITH E; SIEMENS MEDICAL SOLUTIONS
摘要:Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

专利号:US-7714115-B2
优先权日:2004-10-05
标 题 :Method of deprotection
发明人：GRIGG JULIAN; OSBORN NIGEL
权利人:GE HEALTHCARE LTD
摘要:The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the deprotected product are carried out by the addition of a neutralisation agent. The deprotected product is buffered in a pH range suitable for subsequent autoclaving and formulation into an injectable radiopharmaceutical.