CAS: 979-02-2; 16-Dehydropregenolone Acetate

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CAS号108-24-7 乙酸酐 | CAS号126-17-0 澳洲茄胺； 澳州茄胺 | CAS号2309-38-8 furosta-5,20(22... | CAS号34209-81-9 16,17-alpha环氧孕烯醇酮醋酸酯 | CAS号64-19-7 冰醋酸 | CAS号3517-38-2 Pregn-5-en-20-o... | CAS号115375-60-5 (3BETA)-雄甾-5,16... | CAS号109-92-2 乙烯基乙醚 | CAS号23549-24-8 (20E)-3beta-Hyd... | CAS号50678-52-9 16-alpha-chloro... | CAS号1045-71-2 16-DEHYDROPREGN... | CAS号34209-81-9 16,17-alpha环氧孕烯醇酮醋酸酯 | CAS号387-79-1 17α-羟孕烯醇酮 | CAS号1434-54-4 5-孕烷-3β-醇-20-酮-... | CAS号14413-03-7 Phosphonicacid,... | CAS号1778-02-5 孕烯醇酮醋酸酯 | CAS号83509-40-4 (20R)-pregnadie... | CAS号62014-21-5 3β-acetoxy-preg... | CAS号59042-34-1 (3β,20S)-pregn-... | CAS号516-55-2 别孕烯醇酮

薯蓣皂素置于chromium(Vi) Oxide,Sodium Hydrogensulfite,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 5.0H,反应生成 16-脱氢孕烯醇酮乙酸酯
参考文献:Crystal Structure Of 3β-Acetoxy-Pregna-5,16-Dien-20-One (16 Dpa)
标题:Crystal Structure Of 3β-Acetoxy-Pregna-5,16-Dien-20-One (16 Dpa)
摘要:标题化合物3β-乙酰氧基-孕甾-5,16-二烯-20-酮,分子式c23H32O3,是通过薯蓣皂苷元的乙酰化和氧化合成的,其晶体结构已通过单晶x射线衍射数据解析.该化合物属于正交晶系,空间群p212121,晶胞参数为:A = 6.031(4) å,B = 12.481(2) å,C = 27.162(5) å,Z = 4.晶体结构已对1291个观测反射进行精修,最终的r值为0.0597.化合物的a环和c环为椅式构象,B环为半椅式构象,D环为信封式构象.a/b环融合近似反式,B/c和c/d环系统分别通过c8-c9和c13-c14键反式融合.甾核有轻微扭曲,表现为c19-c10⋅c13-c18的假二面角为9.5°.晶体堆积除了范德华相互作用外,还包括一对较弱的c-h⋅o氢键.
DOI:10.1007/s10870-005-9000-5

专利信息

专利号:US-2005085452-A1
优先权日:2002-09-03
标 题:Process for the synthesis of pharmacologically active (z/e)-guggulsterones
发明人：GOKARAJU GANGA R; GOKARAJU RAMA R; GOTTUMUKKALA VENKATA S; SOMEPALLI VENKATESWARLU
摘要:The invention relates to an improved process for producing pharmacologically active synthetic stereoisomeric mixture of guggulsterones (4) in the three steps. The mixture of gugguisterones consists of Z-guggulsterone [4,17(20)-trans-pregnadiene-3,16-dione] and E-guggulsterone [4,17(20)-cis-pregnadiene-3,16-dione] and could be in any relative ratio. This improved process comprises (a) epoxidation of 16-dehydropregnanolone acetate (1) with hydrogen peroxide (b) reduction of the so obtained epoxide (2) with hydrazine hydrate and (c) oxidation of the diol (3).

专利号:US-2004024230-A1
优先权日:2002-04-29
标 题:Synthesis of cyproterone acetate

专利号:US-2006211873-A1
优先权日:2002-04-29
标 题 :Synthesis of cyproterone acetate
发明人：MANOSROI ARANYA; MANOSROI JIRADEJ; BUDDHASUKH DUANG; SRIPALAKIT PATTANA; MAIER ROLAND; WERNER ROLF G
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to improved methods for synthesising cyproterone acetate (17α-Acetoxy-6-chloro-1α, 2(α-methylene-4,6-pregnadiene-3,20-dione) from solasodine.

专利号:CN-114425329-B
优先权日:2022-03-10
标 题 :Catalyst for synthesis of pregnenolone acetate, preparation method and application thereof

专利号:JP-2005523927-A
优先权日:2002-04-29
标 题 :Improved synthesis of cyproterone acetate.

专利号:CN-103214545-A
优先权日:2013-05-08
标题:Improved Synthesis of 3β-Hydroxy-16α, 17α-epoxy-5-pregnene-20-one