CAS: 113118-81-3; 5-Bromonicotinaldehyde

该化合物是一种多用途溴化丙烯衍生物,广泛用作有机合成和制药研究的关键中间体,其甲醛功能组和五点的溴替代体在交叉反应,核生殖器添加和异环变中具有选择性反应.该化合物在生物活性分子,农用化学和功能材料的合成中特别宝贵.其高纯度和稳定性使其适合于医药化学和材料科学的精确应用. 存在电药用和卤化场所都允许高效衍生,有利于复杂的分子结构的建设.

英文名称5-Bromonicotinaldehyde
中文名称5-溴-3-吡啶甲醛
IUPAC名称5-bromonicotinaldehyde
其它别名3-溴-5-甲酰基吡啶; 5溴吡啶3甲醛; 5-Bromo-3-Pyridinecarboxaldehyde
CAS编号113118-81-3
MFCD编号:MFCD03265758
EINECS号:628-546-0
FDA UNII编号:F35HA8F359
分子式:C6H4BrNO
分子量:186.01
产品CID: 161504
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: NGUVGKAEOFPLDT-UHFFFAOYSA-N
InChI=1S/C6H4BrNO/c7-6-1-5(4-9)2-8-3-6/h1-4H…
计算化学: 氢键受体数2.0氢键供体数0可旋转键数1

相似化合物

20826-04-4 20986-40-7 29681-44-5

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
皮肤腐蚀/刺激类别2
严重眼刺激类别2
皮肤致敏类别1
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H317 |可能引起皮肤过敏反应.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xi,Xn
安全声明26-36/37/39
危险类别码22-36/38-43
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

5-bromonicotinoyl chloride (5-bromopyridin-3-yl)methanol 3-Bromo-5-formyl-2H-pyridine-1-carboxylic acid phenyl ester (5-Bromo-pyridin-3-yl)-(2-dimethoxymethyl-4,5-dimethoxy-phenyl)-methanol 3-amino-3-(5-bromopyridin-3-yl)propionic acid 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine 3-bromo-5-(piperidin-1-ylmethyl)pyridine

合成工艺路线路线简述

N,N-二甲基甲酰胺置于异丙基氯化镁,碳酸氢钠,溶剂黄146,Lithium Chloride体系中,用四氢呋喃用作溶剂,化学反应 0.67H,反应生成5-溴吡啶-3-甲醛
参考文献:Inhibitors Of Checkpoint Kinases
标题:Inhibitors Of Checkpoint Kinases
摘要:本发明提供了包含替代三唑喹唑啉酮的化合物,这些化合物抑制chk1活性.本发明还提供了包含这种抑制化合物的组合物,以及通过将该化合物给予需要癌症治疗的患者来抑制chk1活性的方法.

海关参考信息

2912110000-甲醛
2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9744252-B2
优先权日:2011-08-17
标题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
发明人：BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER
权利人:PIRAMAL IMAGING SA
摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

专利号:EP-2230242-B1
优先权日:2009-03-16
标题 :Synthesis of new asymmetrically meso-substituted water-soluble porphyrins acting as cytostatic agents
发明人：HAEUBL MARTIN; SCHOEFBERGER WOLFGANG; SCHUERZ SUSANNE; MUELLER NORBERT; SVEJDA BERNHARD; PFRAGNER ROSWITHA
权利人:JOHANNES KEPLER UNI

专利号:EP-2230242-A1
优先权日:2009-03-16
标题 :Synthesis of new asymmetrically meso-substituted water-soluble porphyrins acting as cytostatic agents

专利号:CN-107628990-B
优先权日:2017-11-10
标题:Synthesis method of 5-bromopyridine-3-formaldehyde

专利号:CN-116120226-A
优先权日:2022-12-28
标题 :Synthesis process of 5-hydroxymethyl nicotinonitrile