CAS: 114772-34-8; Methyl 4'-Methyl-[1,1'-Biphenyl]-2-Carboxylate

上下游产品

CAS号7148-03-0 2-(对甲苯基)苯甲酸 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号610-94-6 2-溴苯甲酸甲酯 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号610-96-8 邻氯苯甲酸甲酯 | CAS号106-38-7 对溴甲苯 | CAS号7440-66-6 锌标准溶液 | CAS号75-36-5 乙酰氯 | CAS号7148-03-0 2-(对甲苯基)苯甲酸 | CAS号528560-93-2 4'-[[[2-正丙基-4-甲... | CAS号114772-38-2 2-[4-(溴甲基)苯基]苯甲酸甲酯 | CAS号114772-40-6 4'-溴甲基联苯-2-甲酸叔丁酯 | CAS号114772-36-0 4'-甲基-[1,1'-联苯]... | CAS号144701-48-4 替米沙坦 | CAS号16191-28-9 4-甲基-联苯-2-甲醛 | CAS号114772-35-9 2-(4-methylphen... | CAS号114798-32-2 2-[4-[[2-but-1-...

2-溴苯甲酸置于2-双环己基膦-2',6'-二甲氧基联苯,硫酸,Palladium Diacetate,Sodium Carbonate体系中,用 水,乙腈 用作溶剂,化学反应 5.0H,反应生成4'-甲基联苯-2-羧酸甲酯
参考文献:Electronic Effects On The Substitution Reactions Of Benzhydrols And Fluorenyl Alcohols. Determination Of Mechanism And Effects Of Antiaromaticity
标题:Electronic Effects On The Substitution Reactions Of Benzhydrols And Fluorenyl Alcohols. Determination Of Mechanism And Effects Of Antiaromaticity
摘要:将联苯酚融合成氟酚,发现它并不影响取代反应的电子敏感性,这表明中间体的反芳香性仅用于减慢过程.
Doi:10.1039/c5Ob01637A

专利信息

专利号:US-11485721-B2
优先权日:2017-11-21
标 题:Method for the metal-free preparation of a biaryl by a photosplicing reaction and their uses
发明人：KLOSS FLORIAN; NEUWIRTH TONI; HAENSCH VEIT; HERTWECK CHRISTIAN
权利人:LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST HKI; LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST
摘要:The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II)→Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

专利号:IT-MI990749-A1
优先权日:1999-04-13
标题 :METHOD FOR THE SYNTHESIS OF DERIVATIVES OF 2-4-METHYLPHENYL BENZOIC ACID