CAS: 123715-02-6; (S)-2-Amino-3-(4-Hydroxy-2,6-Dimethylphenyl)Propanoic Acid

相似化合物

126312-63-8 2108806-15-9 206060-54-0

上下游产品

(S)-N-Acetyl-2,6-Dimethyltyrosine 1333148-31-4
2-乙酰氨基-3-(4-羟基-2,6-二甲基苯基)丙酸 N-Acetyl-2,6-Dimethyl-Dl-Tyrosine 1255098-61-3
N-Boc-2,6-二甲基-L-酪氨酸 (S)-N-Boc-2,6-Dimethyltyrosine 99953-00-1
N-Acetyl-2,6 Dimethyl-O-Methyl-(S)-Tyrosine Methyl Ester 126312-59-2
(S)-3-(4-苄氧基-2,6-二甲基苯基)-2-叔丁氧基羰基氨基丙酸 (S)-O-Benzyl-N-(Tert-Butoxycarbonyl)-2,6-Dimethyltyrosine 945669-52-3

[4-(氯甲基)-3,5-二甲基苯基]碳酸乙酯置于盐酸,六甲基磷酰三胺,正丁基锂,Lithium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 8.17H,反应生成2',6'-二甲基-L-酪氨酸
参考文献:(S)-2',6'-二甲基酪氨酸的高效且高度不对称合成
标题:(S)-2',6'-二甲基酪氨酸的高效且高度不对称合成
摘要:非天然氨基酸 (S)-2,6-二甲基酪氨酸 [(S)-Dmt,图 1] 是用于制备阿片受体调节剂的非常重要的小分子.它已被用来有效地提高...
Doi:10.1080/00304948.2020.1798729

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:WO-2025128985-A1
优先权日:2023-12-14
标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.

专利号:US-10112976-B2
优先权日:2014-06-30
标 题:Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
发明人：ZHAO XINJUN; ZHENG MINYU; YU XIAOZHONG; GAO HANRONG; CORNILLE FABRICE
权利人:FLAMMA SPA
摘要:The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

专利号:US-11440881-B2
优先权日:2019-05-09
标题 :Thiosemicarbazates and uses thereof
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.