CAS: 1405-86-3; Glycyrrhizic Acid

上下游产品

CAS号30430-55-8 Glycyrrhizin tr... | CAS号149553-79-7 | CAS号60192-37-2 Penta-acetylgly... | CAS号6556-12-3 D-葡萄糖醛酸 | CAS号471-53-4 甘草次酸; beta-甘草亭酸 | CAS号53-96-3 2-乙酰氨基氟

在 Calcium Sulfate,氢氧化钾,Sodium Methylate,Silver Trifluoromethanesulfonate,1,1,3,3-四甲基脲体系中,用 甲醇,乙醇,二氯甲烷,水 用作溶剂,化学反应 6.0H,反应生成甘草酸
参考文献:Syntheses Of Glycyrrhetic Acid .Alpha.-Diglycosides And Enol .Alpha.-Glycosides.
标题:Syntheses Of Glycyrrhetic Acid .Alpha.-Diglycosides And Enol .Alpha.-Glycosides.
摘要:甘草酸α-单糖苷衍生物 8,10 和 12 均在吡喃糖环的 C-2 位上具有三氯乙酰基,在 0oc 下用 Nh3 饱和醚处理后,可分别得到相应的醇 13,15 和 17 以及 2'-氯二衍生物 14,16 和 18.在 Agotf 存在下,醇 13,15 和 17 与 2,3,4-三-O-乙酰基-α-D-葡糖酸吡喃糖基溴化物 19 在干燥的 Ch2Cl2 中发生糖基化反应,分别得到相应的 α-二糖苷 20,22 和 24 以及烯醇 α-糖苷 21,23 和 25.将分子中没有反应性 Oh 基团的二糖苷衍生物 20,22 和 35 与反应时间较长的 19 进行糖基化,可分别定量得到烯醇 α-糖苷衍生物 21,23 和 36.单糖苷衍生物 37 在吡喃糖环的 C-4 位上有一个反应性很差的 Oh 基团,用 19 进行糖基化反应可得到烯醇 α-糖苷 38.研究了形成烯醇 α-糖苷的机理.用 1.5N Naome In Meoh 和 5% Koh In Etoh-H2O (1 : 1) 相继处理 20,22 和 24,去除其保护基团,得到游离的 α-二糖苷 26-28;用 5% Koh In Etoh-H2O (1 : 1) 在回流下处理 31,21,23,25 和 36,去除其保护基团,分别得到游离的烯醇 α-糖苷 41-45.
Doi:10.1248/cpb.42.1016

专利信息

专利号:US-9662347-B2
优先权日:2010-05-11
标题 :Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:LEE BONG HEE; BYUN KYUNG HEE; GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND
摘要:The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.

专利号:US-2017204442-A1
优先权日:2014-05-29
标题 :Enzymatic synthesis of soluble glucan fiber
发明人：DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

专利号:WO-2005079742-A1
优先权日:2004-02-19
标 题:Cosmetic and/or dermatological agent for increasing the endogenous lipid content of the skin
发明人：VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE
权利人:STOCKHAUSEN CHEM FAB GMBH; VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE
摘要:The invention relates to the use of at least one active ingredient that is selected from the water-soluble groups: (a) allantoin; (b) salts and/or esters of gluconic acid and/or aspartic acid; (c) precursors of creatine, creatine and creatinine and their derivatives; (d) glycyrrhetinic acid or the salts and/or esters thereof; (e) D-panthenol and/or at least one active ingredient that is selected from the oil-soluble groups: (f) vitamin E acetate; (g) cholesterol; (h) derivatives of glycyrrhetinic acid, in so far as they are soluble in the oils and fats that are conventionally used in the cosmetic industry; (i) vegetable oils and fats; (j) non-saponifiable fractions of vegetable fats. Said active ingredients are used alone or in combination with one or more active ingredients from the groups (a) to (j) to produce a cosmetic and/or dermatological agent for stimulating the endogenous synthesis of barrier substances, in particular for increasing the endogenous lipid content of the skin.

专利号:US-11773128-B2
优先权日:2019-03-28
标题 :Electrocatalytic synthesis of dihydrochalcones
发明人：REDKO MIKHAIL; SAFFRON CHRISTOPHER M; JACKSON JAMES E
权利人:UNIV MICHIGAN STATE
摘要:The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone.

专利号:US-2017198323-A1
优先权日:2014-05-29
标题:Enzymatic synthesis of soluble glucan fiber
发明人：CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; PAYNE MARK S; PRASAD JAHNAVI CHANDRA
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

专利号:US-2017198322-A1
优先权日:2014-05-29
标题:Enzymatic synthesis of soluble glucan fiber
发明人：CHENG QIONG; DICOSIMO ROBERT; ELIOT ANDREW C; OUWEHAND ARTHUR; ROESCH BRIAN MICHAEL; ROTHMAN STEVEN CARY; RUEBLING-JASS KRISTIN; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.