CAS: 162358-07-8; 1-(2-Iodoethyl)-4-Octylbenzene

上下游产品

CAS号219307-01-4 1-(4-(2-iodoeth... | CAS号162358-06-7 4-辛基苯乙醇甲磺酸酯 | CAS号162358-05-6 乙酸-[2-(4-辛基苯基)]乙醇 | CAS号162358-04-5 乙酸-[2-(4-辛基苯基)]乙酯 | CAS号111-64-8 辛酰氯 | CAS号103-45-7 乙酸苯乙酯 | CAS号162358-03-4 乙酸-[2-(4-辛酰基苯基)]乙酯 | CAS号501-94-0 对羟基苯乙醇 | CAS号58556-55-1 2-(4-Hydroxyphe... | CAS号162358-09-0 2-乙酰胺基-2-(4-辛基苯... | CAS号249289-10-9 N-(1,1-双(羟甲基)-3... | CAS号162359-55-9 芬戈莫德 | CAS号162358-08-9 二乙基2-乙酰胺基-2-(4-...

乙酸苯酯置于三乙基硅烷,Aluminum (III) Chloride,Sodium Methylate,三乙胺,三氟乙酸,Sodium Iodide体系中,用 四氢呋喃,甲醇,二氯甲烷,1,2-二氯乙烷 用作溶剂,化学反应 6.5H,反应生成4-(2-碘代乙基)辛基苯
参考文献:Preparation Of Fingolimod And Its Salts
标题:Preparation Of Fingolimod And Its Salts
摘要:本申请提供了制备非格列酮及其药用可接受盐的过程,非格列酮盐酸盐的纯化过程以及非晶态非格列酮盐酸盐的制备过程.

专利信息

专利号:US-9815772-B2
优先权日:2013-03-05
标题:Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof
发明人：KUMAR KOTHAKONDA KIRAN; ASWATHANARAYANAPPA CHANDRASHEKAR; CHANDREGOWDA DHARSHAN JAKKALI; DUVVA CHANDRASEKHAR; PULLELA VENKATA SRINIVAS
权利人:BIOCON LTD
摘要:The present disclosure relates to processes for the preparation of 2-amino-1,3-propane diol compounds and their hydrochloride salts. Particularly, the present disclosure relates to processes for synthesizing 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol and its hydrochloride salt 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride respectively. The said process is safe, commercially feasible for large-scale synthesis and has improved efficacy along with many other advantages. The present disclosure also relates to the novel polymorphs of 2-amino-1,3-propane diol compound and its hydrochloride salt, where in 2-amino-1,3-propane diol compound is 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol, and its hydrochloride salt is 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride.