CAS: 17829-05-9; N,N-Bis(Trideuteriomethyl)Nitrous Amide

上下游产品

CAS号16355-69-4 Nitrosyl hydride-d1

亚硝基二甲胺置于重水,Sodium Methylate体系中,化学反应 10.0H,以50%的收率获得氘代n-亚硝基二甲胺 D6
参考文献:Identification Of Unexpected Unlabeled N,N-Dimethylamide Formation In The Synthesis Of Deuterated Fragment Of Ribociclib By A Hatu-Mediated Coupling Reaction
标题:Identification Of Unexpected Unlabeled N,N-Dimethylamide Formation In The Synthesis Of Deuterated Fragment Of Ribociclib By A Hatu-Mediated Coupling Reaction
摘要:从 N,N-二甲胺和 D2O 开始,合成了 Ribociclib 的氚代片段,用作质谱内标.此外,还对酰胺化反应过程中 D0(未标记物质)的形成进行了系统研究,从而确定了一种偶联试剂 Hatu(o-(7-氮杂苯并三唑-1-基)-N,N,N',N'-四甲基脲六氟磷酸盐)是主要原因.最后,我们设计了一条替代路线,使用 Edci/hobt 作为偶联试剂,生成所需的无 D0 残留的氚代化合物.
Doi:10.1002/jlcr.3690

专利信息

专利号:WO-2024057083-A1
优先权日:2022-11-28
标 题 :Process for the synthesis of selectively alkylated cyclodextrins
发明人：IVÃ?NYI RÓBERT; TUZA KATA; SZENTE LAJOS; PUSKÃ?S ISTVÃ?N; SZÅ?CS LEVENTE; KURKAYEV ABDULA
权利人:CYCLOLAB CYCLODEXTRIN R&D LABORATORY LTD
摘要:The present invention generally relates to a process for the synthesis of selectively alkylated cyclodextrins. More particularly, the present invention relates to a process of cyclodextrin alkylation in a selective manner yielding hexakis(2,6-di-O-alkyl)-alpha-cyclodextrin, heptakis(2,6-di-O-alkyl)-beta-cyclodextrin and octakis(2,6-di-O-alkyl)-gamma-cyclodextrin.

专利号:EP-4626935-A1
优先权日:2022-11-28
标题:Process for the synthesis of selectively alkylated cyclodextrins