CAS: 23611-75-8; Methyl 6-Chloropyrazine-2-Carboxylate

相似化合物

23688-89-3 1240602-95-2 1802251-49-5

上下游产品

CAS号770-00-3 METHYL2-PYRAZIN... | CAS号6164-79-0 2-吡嗪羧酸甲酯 | CAS号85661-24-1 Pyrazinecarboxy... | CAS号148673-71-6 6-氯-吡嗪羰酰氯(9ci) | CAS号23688-89-3 6-氯吡嗪-2-羧酸 | CAS号34597-54-1 1,6-dihydro-6-o... | CAS号35042-26-3 吡嗪-2,6-二羧酸二甲酯 | CAS号77775-49-6 Pyrazinecarboxa... | CAS号940-07-8 吡嗪-2,6-二羧酸

3-Methoxycarbonylpyrazine 1-Oxide置于氯化亚砜体系中,化学反应 8.0H,以67%的收率获得6-氯-2-吡嗪甲酸甲酯
参考文献:Selective Ligands For The Neuronal Nicotinic Receptors And Uses Thereof
标题:Selective Ligands For The Neuronal Nicotinic Receptors And Uses Thereof
摘要:本申请描述了公式(i)的选择性配体,用于神经元尼古丁受体(nnrs),更具体地用于α4β2 Nnr亚型,以及其组合物和使用方法,其中x,R1,X,R2,R3,L1,M,N,P和q在规范中有定义.

专利信息

专利号:US-2024335442-A1
优先权日:2021-08-02
标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.

专利号:EP-3686190-A1
优先权日:2013-07-11
标 题 :Synthesis of therapeutically active compounds

专利号:WO-2024159287-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting hydroxamates, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The invention relates to Nav1.7- and/or Nav1.8-inhibiting hydroxamates. More specifically, the present invention relates to hydroxamates that comprise formula (I): (I), in which the substituents R1 to R10, as well as the derivatives thereof, R11 to R20, are selected independently of the groups defined in the description, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

专利号:WO-2024159286-A1
优先权日:2023-01-30
标题:Nav1.7- and/or nav1.8-inhibiting phenolic compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The invention relates to Nav1.7- and/or Nav1.8-inhibiting phenolic compounds. More specifically, the present invention relates to phenolic compounds of formula (I): (I), in which the substituents R1 to R12 are selected independently of the groups defined in the description, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

专利号:WO-2024159285-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting aryl pyridine compounds. More specifically, the present invention relates to aryl pyridines comprising formula (I): (I), in which the substituents R1 to R10 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related diseases.

专利号:WO-2024159284-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting hydrazides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting hydrazides. More specifically, the present invention relates to hydrazides comprising formula (I):(I), in which the substituents R1 to R8 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.