CAS: 24623-65-2; 3-(Tert-Butyl)-2-Hydroxybenzaldehyde

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CAS号50-00-0 甲醛 | CAS号88-18-6 邻叔丁基苯酚 | CAS号7732-18-5 水 | CAS号61072-60-4 6-t-Butyl-2(1,2... | CAS号61072-57-9 7-tert-butyl-be... | CAS号67-66-3 氯仿 | CAS号1342864-99-6 O-(2-formyl-6-t... | CAS号122-51-0 原甲酸三乙酯 | CAS号215033-72-0 2-tert-butyl-6-... | CAS号183017-88-1 3-tert-butyl-5-... | CAS号189139-14-8 2-tert-butyl-6-... | CAS号215033-50-4 6-(anilinomethy... | CAS号352033-68-2 2-tert-butyl-6-... | CAS号153759-58-1 2-羟基-3-叔丁基-5-溴苯甲醛 | CAS号16094-30-7 Benzoic acid,3-... | CAS号372156-92-8 2-tert-butyl-6-... | CAS号72607-35-3 3-tert-butyl-2-... | CAS号83816-59-5 3-Tert-butyl-5-...

2-叔丁基苯酚置于正丁基锂,四甲基乙二胺,Sodium Hydride体系中,用 四氢呋喃,乙醚 用作溶剂,化学反应 2.0H,反应生成3-叔丁基-2-羟基苯甲醛
参考文献:栓菌漆酶抑制剂酰肼-腙的合成及构效关系研究
标题:栓菌漆酶抑制剂酰肼-腙的合成及构效关系研究
摘要:筛选了一系列酰肼-腙 1-3,即带有苯环的酰肼和醛的亚胺衍生物,作为杂色栓菌漆酶的抑制剂.漆酶是一种含铜酶,抑制它可能会阻止或降低在各种生化过程中产生它的植物病原体的活性.进行了动力学和分子模型研究,并对选定的化合物的对接结果进行了讨论.七种 4-羟基苯甲酰肼 (4-Hbah) 衍生物表现出微摩尔活性 Ki = 24-674 µm,具有预期的和理想的竞争性抑制类型.构效关系(sar)分析表明,细长的水杨醛框架对于稳定底物对接位点附近的分子具有关键作用.此外,水杨醛片段中3位上苯基和大叔丁基取代基的存在有利于与漆酶中的底物结合袋发生强相互作用.有趣的是,含有较大 3-叔丁基-5-甲基-或 3,5-二叔丁基-2-羟基-亚苄基单元的 3-和 4-Hbah 衍生物均不与漆酶的活性位点结合,分别充当非竞争性 (Ki = 32.0 µm) 或非竞争性 (Ki = 17.9 µm) 抑制剂.在容易获得
Doi:10.3390/molecules25051255

专利信息

专利号:US-9371334-B2
优先权日:2010-09-22
标题:Synthesis of substituted salicylaldehyde derivatives
发明人：FARMER JAY J; JOB GABRIEL E
权利人:NOVOMER INC
摘要:Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).

专利号:US-9242955-B2
优先权日:2007-04-25
标题 :Synthesis of cyclic carbonates
发明人：NORTH MICHAEL
权利人:NORTH MICHAEL; UNIV YORK
摘要:A process for the production of cyclic carbonates comprising contacting an epoxide with carbon dioxide in the presence of a dimeric aluminum(salen) catalyst, and a co-catalyst capable of supplying Y − , where Y is selected from Cl, Br and I, where the dimeric aluminum(salen) catalyst is of formula I:

专利号:US-9273024-B2
优先权日:2008-03-07
标 题 :Synthesis of cyclic carbonates
发明人：NORTH MICHAEL
权利人:UNIV NEW CASTLE UPON TYNE; UNIV YORK
摘要:A dimeric aluminum(salen) catalyst of formula I: n nwherein: (a) at least one R group is selected from L-A, and/or (b) at least one of X group is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen atom paired with a counterion selected from Cl, Br and I; and/or (c) at least one X group is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A; and/orn n(ii) (a) one R group is L-A′, or (b) one X group is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen forming part of an ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (c) one X group is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A′.

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:US-10851059-B2
优先权日:2016-08-17
标题:Processes and intermediates for NEP inhibitor synthesis
发明人：KLEINBECK-RINIKER FLORIAN KARL; MAFLI IVES; MARTIN BENJAMIN; PENN GERHARD; SEDELMEIER GOTTFRIED; SEDELMEIER JOERG; VENTURONI FRANCESCO
权利人:NOVARTIS AG
摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人：JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.