CAS: 36556-50-0; 1,2-Dichloro-3-Fluorobenzene

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CAS号151169-74-3 2,3-二氯苯硼酸 | CAS号87-61-6 1,2,3-三氯苯 | CAS号348-62-9 4-氯-2-氟苯酚 | CAS号1435-49-0 1,2-二氯-4-氟苯 | CAS号625-98-9 间氯氟苯 | CAS号348-59-4 2,5-二氯氟苯 | CAS号1435-48-9 2,4-二氯氟苯

2,3-二氯苯硼酸置于乙酰基次氟酸酯体系中,用 溶剂黄146,乙腈 用作溶剂,化学反应 0.17H,以45%的收率获得2,3-二氯氟苯
参考文献:直接由稀释氟制成的次氟乙酰基氟氟化芳基硼酸
标题:直接由稀释氟制成的次氟乙酰基氟氟化芳基硼酸
摘要:使用容易获得的acof溶液,可以高收率地将含有edg的芳基硼酸或频哪醇酯转化为相应的芳基氟化物.在与对位含ewg的芳基硼酸发生反应时,会产生两种竞争力:一种将氟化作用直接发生在硼酸上,另一种将其引导向ipso取代.当ewg间位为硼酸时,Ipso向硼部分的取代以非常好的收率发生.
Doi:10.1021/jo401832F

专利信息

专利号:WO-2010058421-A3
优先权日:2008-11-18
标题 :A process for synthesis of 2, 4-dichloro-5- fluoroacetophenone (dcfa)
发明人：MANDAL SISIR; PATIL NARENDRA; SULEMAN INAMDUR; MORE VINOD; PURI PRASHANT
权利人:ADITYA BIRLA SCI & TECH CO LTD; MANDAL SISIR; PATIL NARENDRA; SULEMAN INAMDUR; MORE VINOD; PURI PRASHANT
摘要:A process for synthesis of 2,4-dichloro-5-fluoro acetophenone (DCFA) is disclosed. The process comprises first reacting 3,4-dichloronitrobenzene with potassium fluoride having bulk density in the range of 0.2 to 1.3, to form a fluorinated intermediate product, then reacting the intermediate product with chlorine to form dichlorofluorobenzene and finally acylating dichlorofluorobenzene using an acylating agent to form a mixture containing DCFA along with impurities, followed by purification and enrichment of DCFA in the mixture by melt crystallization.

专利号:US-4621160-A
优先权日:1983-06-23
标题 :Process for the chlorination of aromatic derivatives
发明人：DESBOIS MICHEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the chlorination of aromatic derivatives. The aromatic derivative is reacted with chlorine gas in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.

专利号:WO-2010058421-A2
优先权日:2008-11-18
标题:A process for synthesis of 2, 4-dichloro-5- fluoroacetophenone (dcfa)

专利号:CN-105130744-A
优先权日:2015-08-19
标题 :Synthesis of 1,3,5-trichloro-2,4,6-trifluorobenzene from a 2,4-difluoro-3,5-dichloronitrobenzene

专利号:CN-1007150-B
优先权日:1987-06-22
标题 :Synthesis of 2,4-dichlor-5-fluor benzoic acid

专利号:US-5721099-A
优先权日:1992-10-01
标 题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.