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专利信息
专利号:US-5369017-A
优先权日:1994-02-04
标题 :Process for solid phase glycopeptide synthesis
发明人:WONG CHI-HUEY; SCHUSTER MATTHIAS
权利人:SCRIPPS RESEARCH INST
摘要:A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support to which is linked a two-part spacer group having a chain length of about 12 to about 40 methylene groups. The first part of the spacer is covalently bonded to the silica-based support and has a length of about 3 to about 10 methylene groups. The second spacer part is covalently bonded to the first part of the spacer and comprises the distal end of the two part spacer. The second part is soluble as a free molecule in each of water, dimethylformamide and dichloromethane and has a terminal amine or hydroxyl group to which the C-terminal residue of the peptide portion of the glycopeptide chain is bonded. The chain of atoms connecting the desired glycopeptide to the solid phase matrix also includes a moiety having a selectively severable bond which on cleavage of that bond separates the matrix from whatever else is bonded to that moiety.
专利号:US-6489499-B1
优先权日:2002-03-11
标 题 :Siloxane modified carboxylic acid substituted amines and salts thereof
发明人:KING WAYNE; MACMILLAN JOHN H; TELEPCHAK MICHAEL J
权利人:UNITED CHEMICAL TECHNOLOGIES I
摘要:Novel compounds comprising siloxane modified carboxylic acid substituted amines and salts thereof are provided. The compounds according to the invention provide many of the desirable properties of ethylenediamine tetraacetic acid and its salts in a stationary phase. A process for synthesis of the compounds according to the invention are also provided.
专利号:US-2008069887-A1
优先权日:2006-09-15
标 题 :Method for nanoparticle surface modification
发明人:BARAN JIMMIE R; FANSLER DUANE D
权利人:3M INNOVATIVE PROPERTIES CO
摘要:The present disclosure discloses a method for making surface-modified nanoparticles. The surface of a nanoparticle is modified with an aminorganosilane and an alkylating agent in a one-pot synthesis to provide alkylamine surface-modified nanoparticles.
专利号:US-2005106596-A1
优先权日:2003-08-27
标题:Nucleic acid analysis methods conducted in small reaction volumes
发明人:SKRZYPCZYNSKI ZBIGNIEV; BAIER JOERG; NICHOLS KARL
权利人:THIRD WAVE TECH INC
摘要:The present invention relates to reactions conducted on or in solid surface materials, including liquid phase reactions within capillary tubes and arrays of capillary tubes or open end reaction microchambers. A wide array of biomolecular and combinatorial synthesis reactions may be used with the present invention. For example, the present invention provides methods for forming and cleaving nucleic acid cleavage structures on or in solid surface materials.
专利号:JP-5382400-B2
优先权日:2008-02-05
标题:Synthesis method of organic-inorganic composite