CAS: 8002-33-3; Sulfonated Castor Oil

专利信息

专利号:US-2009325918-A1
优先权日:2008-06-16
标 题:Synthesis and separation of optically active isomers and cyclopropyl derivatives of spironolactone and their biological action
发明人：SOMBERG JOHN C; RANADE VASSANT V
权利人:SOMBERG JOHN C; RANADE VASSANT V
摘要:Methods for separation and synthesis of the optically active 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone are provided. Preferred stereoisomerically purified 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone have fewer effects mediated by gonadal steroid receptors relative to effect mediated by minteralocorticoid progesterone receptors, compared to the stereoisomerically unpurified form of the compound. These optically active compounds can be useful for obtaining reduction in moderate essential hypertension and it the treatment of congestive heart failure in humans with minimized undesirable side effects such as gynecomastia, tender breast enlargement and menstrual irregularities in women, and loss of libido in men.

专利号:US-2006025421-A1
优先权日:2004-06-25
标 题:Pyridyl piperazines for the treatment of CNS disorders
发明人：BRODNEY MICHAEL A
权利人:PFIZER
摘要:This invention is directed to compounds of Formula I and to pharmaceutical compositions comprising the compound of Formula I. n n where the dashed line represents an optional double bond; and where n is 1 or 2, and Ar 1 , Ar 2 , . . . and Z are as defined in the specification. The invention is also directed to a method of treating a disorder or condition that can be treated by altering serotonin-mediated neurotransmission, such as migraine, headache, cluster headache, anxiety, depression, etc. This invention is also directed to intermediates useful in the synthesis of compounds of Formula I.

专利号:US-5229335-A
优先权日:1991-11-01
标题 :Ceramic materials and their synthesis by a xerogel process
发明人：SALOMON ROBERT E; MACHO JORGE J
权利人:UNIV TEMPLE
摘要:The invention provides a process for producing high phase purity ceramic materials through the utilization of organic gelling agents. The process comprises the following steps: (a) dissolving stoichiometric amounts of metal salts in a solvent to form a solution; (b) heating the solution to a temperature sufficient to dissolve the gelling agent; (c) dissolving from about 0.1 to about 50 weight percent of an organic gelling agent into the heated solution; (d) cooling the solution to form a gel; (e) drying the gel to form a xerogel precursor; and (f) subjecting the xerogel precursor to a calcination process to produce a high phase purity ceramic material.

专利号:US-4665092-A
优先权日:1985-10-03
标 题 :Styrene derivatives, their use as antiallergic agents and intemediate epoxides for their synthesis
发明人：FERRO MICHAEL P; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R 1 =H or CH 3 ; R 2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R 4 and R 5 =alkyl; n=O or 1; and R 3 is as described.

专利号:US-4814487-A
优先权日:1986-09-26
标 题:Amido substituted naphthalenes and intermediates thereof
发明人：MURRAY WILLIAM V; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.

专利号:WO-2008134578-A2
优先权日:2007-04-28
标题 :Synthesis of optically active radio-labeled reverse transcriptase inhibitors