CAS: 1190389-15-1; (S)-N-(4-(((2S,5R)-5-((R)-Hydroxy(Phenyl)Methyl)Pyrrolidin-2-yl)Methyl)Phenyl)-4-Oxo-4,6,7,8-Tetrahydropyrrolo[1,2-A]Pyrimidine-6-Carboxamide

上下游产品

Tert-Butyl(2R,5S)-2-[(R)-Hydroxy(Phenyl)Methyl]-5-[4-({[(6S)-4-Oxo-4,6,7,8-Tetrahydropyrrolo[1,2-α]Pyrimidin-6-Yl]Carbonyl}Amino)Benzyl]Pyrrolidine-1-Carboxylate 1190393-25-9
(S)-4-Oxo-4,6,7,8-Tetrahydropyrrolo[1,2-A]Pyrimidine-6-Carboxylic Acid Methyl Ester 1190392-23-4

(R)-((R)-5-(4-Nitrobenzyl)-3,4-Dihydro-2H-Pyrrol-2-yl)(Phenyl)Methanol置于吡啶,盐酸,甲醇,5% Pt/al2O3,氢气,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺体系中,用 四氢呋喃,N,N-二甲基乙酰胺,水,异丙醇 用作溶剂,50.0 °C,790.82 Kpa 条件下,反应 26.5H,反应生成维贝格龙
参考文献:合理设计用于高ph动态动力学还原的酮还原酶合成的vibegron
标题:合理设计用于高ph动态动力学还原的酮还原酶合成的vibegron
摘要:此处描述的是在高ph环境中进行的酶促动力学动力学还原可实现的vibegron的高效立体选择性合成.为了克服在这些条件下的酶性能限制,通过计算和结构上辅助的策略发展了酮还原酶,以通过更紧密的结合增加辅因子的稳定性.
Doi:10.1002/anie.201802791

专利信息

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:WO-0168615-A1
优先权日:2000-03-13
标题 :Quinazoline synthesis
发明人：DENER JEFFREY MARK; LEASE TIMOTHY G; NOVACK AARON ROBERT
权利人:CHEMRX ADVANCED TECHNOLOGIES I; DENER JEFFREY MARK; LEASE TIMOTHY G; NOVACK AARON ROBERT
摘要:The present invention relates to a method for making a compound of Formulas I, II and III. The method of the present invention also enables parallel and simultaneous synthesis of a plurality of compounds represented by Formulas I, II and III.

专利号:BR-122018077504-B1
优先权日:2009-11-13
标题 :METHODS FOR SYNTHESIS OF SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS

专利号:CN-118240785-A
优先权日:2024-04-30
标 题:Novel carbonyl reductase mutant and application thereof in synthesis of virbegron intermediates

专利号:EP-3406142-B1
优先权日:2009-11-13
标题:Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis

专利号:US-2013231326-A1
优先权日:2009-11-13
标 题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis