CAS: 1243308-37-3; Ethyl 2-((5-Chloropyridin-2-yl)Amino)-2-Oxoacetate Hydrochloride

相似化合物

349125-08-2 552850-73-4 2803477-33-8

2-氨基-5-氯吡啶,草酰氯单乙酯 以 乙腈 用作溶剂,化学反应生成依度沙班杂质c(盐酸盐)
参考文献:Preparation Method Of Optically Active Diamine Compound
标题:Preparation Method Of Optically Active Diamine Compound
摘要:需要解决的问题是提供一种高效生产fxa抑制剂(x)和(x-A)的重要中间化合物(1)和(1A)的方法.其解决方案是使用立体选择性分子内环化反应生产由公式(8D)表示的化合物的方法,并通过去磺酰化化合物(8D)生产化合物(1F)或其盐或水合物的方法.在每个公式中,R4代表c1-C6烷基,苄基等.

专利信息

专利号:US-9809546-B2
优先权日:2016-03-14
标 题 :Process for producing diamine derivative
发明人：LU TZU-CHIANG; CHEN CHIEN-YI; CHENG CHING-SHUEN; MAI CHIN-CHENG
权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD; CHUNGWHA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).