专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:EP-2078025-A2 优先权日:2006-09-22 标 题:Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
专利号:SI-22383-A 优先权日:2006-09-22 标 题:A new process for the synthesis of clopidogrel and a novel form of its pharmaceutically acceptable salts
专利号:WO-2008034912-A2 优先权日:2006-09-22 标 题:Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
专利号:CN-114507650-A 优先权日:2022-01-28 标 题 :Leucine dehydrogenase mutant and application thereof in synthesis of (S) -o-chlorophenylglycine
专利号:CN-114507650-B 优先权日:2022-01-28 标 题 :Leucine dehydrogenase mutants and their application in the synthesis of (S)-o-chlorophenylglycine
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 260. 参考文献:10.1107/s160053681004523x 摘要:Liang YS, Mu S, Liu Y, Liu DK. (R)-[1-(2-Chloro-phen-yl)-2-meth-oxy-2-oxoeth-yl][2-(thio-phen-2-yl)eth-yl]ammonium (+)-camphor-10-sulfonate acetone monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 10;66(Pt 12):o3117.