CAS: 14542-12-2; Thiazol-2-Ylmethanol

相似化合物

10200-59-6 14190-59-1 55842-56-3

上下游产品

CAS号10200-59-6 2-甲酰基噻唑 | CAS号14527-42-5 噻唑-2-羧酸乙酯 | CAS号50-00-0 甲醛 | CAS号16733-85-0 1,3-噻唑-2-羧胺 | CAS号288-47-1 噻唑 | CAS号40610-14-8 lithium,2H-1,3-... | CAS号3029-48-9 Thi°Cyanic acid... | CAS号3364-78-1 2-氯甲基噻唑 | CAS号10200-59-6 2-甲酰基噻唑 | CAS号131654-56-3 2-溴甲基噻唑

2-醛基噻唑置于甲醇,Sodium Tetrahydroborate体系中,化学反应 1.0H,以95%的收率获得2-羟甲基噻唑
参考文献:新型含恶唑单元喹唑啉类似物的设计,合成和生物活性评估
标题:新型含恶唑单元喹唑啉类似物的设计,合成和生物活性评估
摘要:以喹唑啉为骨架,恶唑骨架为取代基,设计合成了一种新型的喹唑啉衍生物,并对其生物学活性进行了抗增殖活性和egfr抑制能力的评价.化合物12B表现出最强的抑制活性(对egfr的ic 50 = 0.95 µmol / L),可以在进一步的研究中将其优化为潜在的egfr抑制剂.合成的喹唑啉类似物和所有中间体的结构通过1 H和13 C NMR,2D NMR光谱,Ir光谱和ms光谱确认.
Doi:10.1002/cjoc.201400271

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-8513429-B2
优先权日:2002-08-23
标 题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; RIVKIN ALEXEY; FUMIKIKO YOSHIMURA; CHOU TING-CHAO; GABARDA ANA E; DONG HUAJIN
权利人:DANISHEFSKY SAMUEL J; RIVKIN ALEXEY; FUMIKIKO YOSHIMURA; CHOU TING-CHAO; GABARDA ANA E; DONG HUAJIN; SLOAN KETTERING INSITUTE FOR CANCER RES
摘要:The present invention provides compounds of formula (I): n n n n n n n n n n n n as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

专利号:US-7875638-B2
优先权日:2002-08-23
标题:Synthesis of epothilones, intermediates thereto, analogues and uses thereof
发明人：DANISHEFSKY SAMUEL J; RIVKIN ALEXEY; YOSHIMURA FUMIHIKO; CHOU TING-CHAO; GABARDA ANA E; DONG HUAJIN; WU KAIDA; MOORE MALCOLM A S; DORN DAVID
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides compounds of formula (I): n n n n n n n n n n n n as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

专利号:US-7384964-B2
优先权日:2002-08-23
标题:Synthesis of epothilones, intermediates thereto, analogues and uses thereof
发明人：DANISHEFSKY SAMUEL J; RIVKIN ALEXEY; YOSHIMURA FUMIHIKO; CHOU TING-CHAO; GABARDA ANA E; DONG HUAJIN; WU KAIDA; MOORE MALCOLM A S; DORN DAVID
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides compounds of formula (I): n nas described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

专利号:US-6921769-B2
优先权日:2002-08-23
标题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; RIVKIN ALEXY; YOSHIMURA FUMIKIKO; CHOU TING-CHAO; GABARDA ANA E
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides compounds of formula (I): n n as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

专利号:US-2004053995-A1
优先权日:2002-08-23
标 题:Synthesis of epothilones, intermediates thereto and analogues thereof