CAS: 18085-97-7; 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-6-Methoxy-4H-Chromen-4-One
该化合物是一种主要见于某些植物的天然浮质化合物,主要见于该植物,特别是* ,其特点是独特的化学结构,包括一种香肠骨,有助于其潜在的生物活动.Jacoosidin由于报告的抗氧化剂,抗炎和抗癌特性,在药理领域引起了兴趣.该化合物显示出一系列生物影响,包括能够调节各种信号路径,从而可能促进其治疗潜力.此外,Jacoosidin以其有机溶剂溶解性为名,这可以影响其生物利用率和生物系统中的功效.对Jageosdin的研究继续探索其在医学领域的行动和潜在应用机制,特别是在开发自然产品以造福健康方面.和许多植物化学学一样,Jageosdin的具体影响和安全特征需要进一步调查,以充分了解其在临床环境中的潜力.
- 英文名称5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-6-Methoxy-4H-Chromen-4-One
- 中文名称棕矢车菊素
- IUPAC名称5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one
- 其它别名5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-6-Methoxy-4H-1-Benzopyran-4-One; Jaceosidin; 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-6-Methoxy-4H-Chromen-4-One; Flavone, 4',5,7-Trihydroxy-3',6-Dimethoxy-
- CAS编号18085-97-7
- MFCD编号:MFCD01081948
- FDA UNII编号:5U4Y68G678
- 分子式:C17H14O7
- 分子量:330.29
- 产品CID: 932856
- 产品分类天然产物 → 黄酮类化合物
物理性质
MSDS等安全信息
上下游产品
CAS号22248-14-2 2,3,4-三甲氧基-6-羟基苯乙酮 | CAS号121-33-5 香草醛 | CAS号51145-80-3 4'-hydroxy-5,6,... | CAS号18003-33-3 2-(3,4-二羟基苯基)-5...合成工艺路线路线简述
2,3,4-三甲氧基-6-羟基苯乙酮置于氢溴酸,碘,溶剂黄146,Potassium Hydroxide体系中,用 甲醇,二甲基亚砜 用作溶剂,化学反应生成棕矢车菊素
参考文献:Oroxylin A Analogs Exhibited Strong Inhibitory Activities Against Inos-Mediated Nitric Oxide (No) Production
标题:Oroxylin A Analogs Exhibited Strong Inhibitory Activities Against Inos-Mediated Nitric Oxide (No) Production
摘要:A Number Of Oroxylin A Analogs Were Prepared And Evaluated For Their Inhibitory Activities Against Inos-Mediated Nitric Oxide (No) Production From Lps-Stimulated Bv2 Cells. The Analogs Were Synthesized From Purchased 2'-Hydroxy-4,5,6-Trimethoxyacetophenone And Aldehydes In 3 Steps. Among The Tested Compounds,Several Analogs (3B,3C,3D,3F) Exhibited Strong Inhibitory Activities. Especially,The Analog With 4-Nitrophenyl Group (3B) Showed Stronger Inhibitory Activity (Ic50 = 4.73 Mu M) Than That Of Wogonin (Ic50 = 7.80 Mu M). (C) 2012 Published By Elsevier Ltd.
Doi:10.1016/j.Bmcl.2012.01.135
海关参考信息
- 2905110000-甲醇
2907210001-间苯二酚
2907221000-对苯二酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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合成参考文献
参考文献:10.1038/s41420-020-00301-2
摘要:Huang R, Gao S, Han Y, Ning H, Zhou Y, Guan H, Liu X, Yan S, Zhou P. BECN1 promotes radiation-induced G2/M arrest through regulation CDK1 activity: a potential role for autophagy in G2/M checkpoint. Cell Death Discovery. 2020 Aug 05;6(1):70. doi: 10.1038/s41420-020-00301-2.
参考文献:10.1021/jf990444i
摘要:Valentão P, Andrade PB, Areias F, Ferreres F, Seabra RM. Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. J Agric Food Chem. 1999 Nov;47(11):4579–82. doi: 10.1021/jf990444i.
参考文献:10.1248/bpb.25.875
摘要:Nagao T, Abe F, Kinjo J, Okabe H. Antiproliferative Constituents in Plants. 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship. Biological & Pharmaceutical Bulletin. 2002;25(7):875–9. doi: 10.1248/bpb.25.875.
参考文献:10.1021/np060217s
摘要:Nakagawa H, Takaishi Y, Tanaka N, Tsuchiya K, Shibata H, Higuti T. Chemical Constituents from the Peels of Citrus sudachi. J. Nat. Prod. 2006 Aug 01;69(8):1177–9. doi: 10.1021/np060217s.
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