CAS: 197520-71-1; 2,3,4-Trifluoro-5-Nitrobenzoic Acid

上下游产品

CAS号61079-72-9 2,3,4-三氟苯甲酸 | CAS号284030-58-6 4-氨基-2,3-二氟-5-硝... | CAS号284030-57-5 4-氨基-2,3-二氟-5-硝基苯甲酸 | CAS号918321-24-1 2,3,4-三氟-5-硝基苯甲酸甲酯 | CAS号918321-31-0 2,4-diamino-3-f... | CAS号606143-94-6 Methyl 4-amino-...

2,3,4-三氟苯甲酸置于硫酸,硝酸体系中,化学反应 3.5H,以97.1%的收率获得2,3,4-三氟-5-硝基苯甲酸
参考文献:An Efficient Synthesis Of 5-Chloro-2,3,4-Trifluorobenzoic Acid
标题:An Efficient Synthesis Of 5-Chloro-2,3,4-Trifluorobenzoic Acid
摘要:5-氯-2,3,4-三氟苯甲酸是制备喹诺酮-3-羧酸衍生物的一种关键中间体,它是通过硝化,选择性还原,重氮化和氯化等反应序列,从市售的 2,3,4,5-三氟苯甲酸中合成的,收率极高.
Doi:10.3184/174751915X14322269913981

专利信息

专利号:US-8183385-B2
优先权日:2005-06-23
标题 :SNAR process for preparing benzimidazole compounds
发明人：DEMATTEI JOHN; SHAKYA SAGAR; NICHOLS PAUL J; BARNETT BRADLEY R; HACHE BRUNO P; EVANS MATTHEW CHARLES; FORD JAMES GAIR; LEONARD JOHN
权利人:DEMATTEI JOHN; SHAKYA SAGAR; NICHOLS PAUL J; BARNETT BRADLEY R; HACHE BRUNO P; EVANS MATTHEW CHARLES; FORD JAMES GAIR; LEONARD JOHN; ARRAY BIOPHARMA INC; ASTRAZENECA AB
摘要:Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-2 and their synthetic intermediates: wherein X 1 , X 2 , X 5 , R 1 , R 2 and R 4 are as defined herein. Compounds of Formula Ia-2 and their synthetic intermediates can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.

专利号:US-5994575-A
优先权日:1996-04-16
标 题 :Phenylenediamines and process for preparing the same
发明人：YAZAKI AKIRA; YOSHIDA JIRO; NIINO YOSHIKO
权利人:WAKUNAGA PHARMA CO LTD
摘要:Phenylenediamines represented by general formula (1): ##STR1## wherein R represents an alkyl group or an optionally substituted aralkyl group, X 1 represents a hydrogen atom or a halogen atom, and X 2 represents a halogen atom; salts thereof, and a process for preparing the same. The compounds are useful as intermediates for synthesis of pyridonecarboxylic acid derivatives useful as antibacterial agents.

专利号:US-6136823-A
优先权日:1996-11-28
标题 :Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
发明人：SAKAE NOBUYA; YAZAKI AKIRA; KURAMOTO YASUHIRO; YOSHIDA JIRO; NIINO YOSHIKO; OHSHITA YOSHIHIRO; HIRAO YUZO; HAYASHI NORIHIRO; AMANO HIROTAKA
权利人:WAKUNAGA PHARMA CO LTD
摘要:PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.