CAS: 2613-23-2; 3-Chloro-4-Fluorophenol

上下游产品

3-chloro-4-fluorophenylamine 1-bromo-3-chloro-4-fluorobenzene 4-chloro-2,5-difluoro-benzoic acid 2-(3-chloro-4-fluorophenoxy)acetic acid 3-(3-chloro-4-fluorophenoxy)butyric acid ethyl (R)-2-(3-chloro-4-fluorophenoxy)propionate (S)-2-(3-Chloro-4-fluoro-phenoxy)-propionic acid ethyl ester

3-氯-4-氟溴苯置于n1,N2-双(2-噻吩甲基)-乙二酰胺,Caesium Carbonate,Copper(I) Bromide,Sodium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应 20.0H,反应生成3-氯-4-氟苯酚
参考文献:从药物化合物库中鉴定铜催化的c-O偶联的草酰胺配体
标题:从药物化合物库中鉴定铜催化的c-O偶联的草酰胺配体
摘要:一个典型的药物化合物库具有分子多样性,可以为发现新的配体结构提供平台.本文中,我们描述了这种方法与高通量筛选的结合使用,以鉴定n,N'-双(噻吩-2-基甲基)草酰胺为配体,通常对铜催化的c-O交叉偶联有效.在温和的条件下都可以同时使用联芳醚和苯酚.
Doi:10.1002/cctc.201900393

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:CN-109134204-A
优先权日:2018-11-16
标 题:Synthesis of intermediate 2-bromo-4-fluoro-5-chlorophenol

专利号:US-9067934-B2
优先权日:2011-03-31
标题 :Bicyclic pyridinones
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-109134204-B
优先权日:2018-11-16
标 题 :Synthesis method of intermediate 2-bromo-4-fluoro-5-chlorophenol

专利号:US-8445510-B2
优先权日:2010-05-14
标题 :Fused bicyclic kinase inhibitors
发明人：MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING
权利人:MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.