CAS: 27214-00-2; Calcium 2,3-Dihydroxypropyl Phosphate

相似化合物

57-03-4 1555-56-2 1319-69-3

专利信息

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-11466046-B2
优先权日:2014-10-08
标题 :14-membered ketolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

专利号:US-2019298851-A1
优先权日:2016-06-01
标 题:Sequential click reactions for the synthesis and functionalization of hydrogel microspheres and substrates
发明人：ALGE DANIEL L; JIVAN FARAZ; YEGAPPAN RAMANATHAN; DODSON COLIN R
权利人:TEXAS A & M UNIV SYS
摘要:The present disclosure describes two click reactions to sequentially polymerize and then functionalize hydrogel microparticles to provide therapeutic agent-functionalized crosslinked hydrogel microparticles. The two click reactions have one common reactive group, and are non-interfering with respect to one another. The therapeutic agents can be released from the hydrogel microparticles over time as the hydrogel degrades, or the therapeutic agents can be released from the hydrogel microparticles by enzymatic degradation or hydrolysis. In some embodiments, the biological function of the therapeutic agents can be preserved or enhanced when covalently bound to the hydrogel microparticles. The present disclosure also provides methods for the production of hydrogel cell culture substrates. The methods overcome the hurdle of protein functionalization through the implementation of an advanced but simple chemical strategy that involves modifying a protein of interest with chemical groups (e.g., tetrazines) that are able to react with complementary chemical groups (e.g., norbornenes) immobilized within a mechanically-tunable hydrogel.

专利号:US-8658218-B2
优先权日:1999-08-17
标 题 :Composition with anti-inflammatory, protein synthesizing, treatment of enzyme deficiency, activating genetic therapy and anti-cancer activity and methods of use
发明人：GIRSH LEONARD S
权利人:GIRSH LEONARD S; IMMUNOPATH PROFILE INC
摘要:A composition for treating damaged tissue and promoting healthy tissue growth, healing and tissue regeneration, wherein the composition comprises an extracellular matrix compound, a surface-active lipid, one or more enantiomericaily pure L-amino acids or glycine, a hydrophilic surfactant with a high HLB, as well as vitamins, minerals or trace elements. Not only does it maintain good health, but the components are non-intrusive, bio-safe, non-coalescent and can mimic normally occurring stem-cells within a body. When applied to diseased tissues, the subject compositions can stimulate, facilitate, and accelerate protein synthesis for the regeneration of diseased organs and tissues. The healing efficacy of these tissue components gives us further appreciation of the protective action of human tissue over and above and other than the immune protective system or perhaps an integral component part of the immune system.

专利号:WO-9800148-A1
优先权日:1996-06-28
标题 :Drug preparations, containing creatine with at least one salt of calcium, magnesium, manganese or zinc
发明人：MEYER HANS
权利人:IPR INST PHARM RES RIEHEN AG; MEYER HANS
摘要:The invention relates to creatine in conjunction with at least one salt from the group of calcium, magnesium, manganese or zinc. Said creatine is suitable for therapeutic construction of the muscle mass with appropriate improvement of muscular functions and stamina, reduction in the recovery phase after physical strain and for a positive change in the ratio of the fat body mass to lean body mass. Said drug preparations are also suitable as a synthesis compound or for preliminary treatment in heart operations, for treatment of heart complaints, respiratory deficiencies, emphysemas, after operations or generally to eliminate states of deficiency and for substitution in periods of increased requirement, and for deficiency of nutrition, for fibromyalgia or for different types of myopathy and cachectic states.