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CAS号1072-85-1 1-溴-2-氟苯 | CAS号201230-82-2 carbon monoxide | CAS号67-56-1 甲醇 | CAS号393-52-2 邻氟苯甲酰氯 | CAS号3240-34-4 碘苯二乙酸 | CAS号445-29-4 邻氟苯甲酸 | CAS号446-51-5 2-氟苄醇 | CAS号124-38-9 二氧化碳 | CAS号348-52-7 邻氟碘苯 | CAS号74-88-4 碘甲烷 | CAS号465514-33-4 2-(吗啉-4-基-苯基)甲醇 | CAS号446-24-2 2-氟亚苯基肼 | CAS号446-51-5 2-氟苄醇 | CAS号3704-28-7 2-(甲硫基)苯甲酸甲酯 | CAS号108593-16-4 2,2-Dimethyl-1,... | CAS号445-29-4 邻氟苯甲酸 | CAS号87066-94-2 2-(1-哌啶基)苄醇 | CAS号61034-86-4 2-(1H-吡咯-1-基)苄基乙醇 | CAS号10333-67-2 2-(1H-吡咯-1-基)苯甲酸甲酯 | CAS号10072-05-6 N,N-二甲基邻氨基苯甲酸甲酯

邻氟苯甲酸置于氯化亚砜,硫酸体系中,化学反应 6.0H,反应生成 邻氟苯甲酸甲酯
参考文献:作为 Ftsz 抑制剂的靛红衍生物的设计,合成和抗菌活性
标题:作为 Ftsz 抑制剂的靛红衍生物的设计,合成和抗菌活性
摘要:摘要 设计了七种靛红衍生物,并通过单晶x射线衍射,1 H NMR,Ms和元素分析对其化学结构进行了表征.结构稳定,然后是分子内和分子间 H 键,使这些分子成为分子识别中与单个分子内的自互补供体和受体单元的完美例子.评价这些化合物的抗微生物活性.已执行对接模拟以将化合物定位到 Ftsz 活性位点,以确定它们可能的结合模型.所有化合物均表现出较好的抗菌活性.有趣的是,化合物5C和5D对金黄色葡萄球菌表现出更好的抗菌活性,Ic 50 值分别为0.03和0.05 μmol/ml.
DOI:10.1016/j.Molstruc.2016.03.036

专利信息

专利号:US-8962858-B2
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
发明人：MITASEV BRANKO; KIM DAE-SHIK; ZHANG HUIMING; FARTHING CHRISTOPHER N
权利人:EISAI R&D MAN CO LTD
摘要:Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

专利号:US-2010035867-A1
优先权日:2006-07-11
标 题 :Inhibitors of Cyclic Nucleotide Synthesis and Their Use for Therapy of Various Diseases
发明人：GUERRANT RICHARD L; KOTS ALEXANDER Y; MURAD FERID; CHOI BYUNG-KWON
权利人:GUERRANT RICHARD L; KOTS ALEXANDER Y; MURAD FERID; CHOI BYUNG-KWON
摘要:We disclose a method of inhibiting activity of adenylyl cyclase or guanylyl cyclase in a mammal by administering to the mammal an amount of a composition effective to inhibit the activity, wherein the composition contains at least one compound selected from the group consisting of structural formulae (Ia) and (Ib) and salts thereof, wherein R1 is —H or has the structure —C(â•?O)R8; R2 is â•?O or has the structure —OC(â•?O)R9; and R3, R4, R5, R6, and R7 are each independently selected from the group consisting of —H, —NO 2 , formula (I), -halogen, —OC(â•?O)R9, —OR9, —OH, —R8OH, —CH 3 , —OC(â•?O)CH 2 Ph, formulae (II), (III), (IV), —OPh, —CF 3 , —R8, —C(â•?O)OR9, -Ph, —R8Ph, formulae (V), (VI), (VII), (VIII), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), (XVII), (XVIII), (XIX), (XX), and (XXI), wherein each R8 is independently a linear or branched hydrocarbon group having from 1 to 4 carbon atoms and each R9 is independently a hydrocarbon group having from 1 to 2 carbon atoms. Administering the composition can be used to treat a disease in a mammal mediated by activity of adenylyl cyclase or guanylyl cyclase and effected by a toxin produced by a pathogenic organism or to reduce cyclic AMP or cyclic GMP levels in a mammal in need of reduction thereof. The composition can also be administered to mammalian cells in vitro. The above methods of inhibiting activity of adenylyl cyclase or guanylyl cyclase and treating diseases via such inhibition can be effective without prolonged treatment, have reversible effects, have low or no toxicity, are highly potent, are unlikely to have side effects, do not act on purinergic recptors, or can negate pathogenic toxins independently of whether the pathogenic organism survives.

专利号:US-8802871-B2
优先权日:2011-01-21
标 题:Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:US-2013197244-A1
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:CA-2814014-A1
优先权日:2011-01-21
标 题:Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:US-10118892-B2
优先权日:2012-10-12
标 题:Compounds and their synthesis
发明人：ARSTAD ERIK; SANDER KERSTIN; GENDRON THIBAULT
权利人:UCL BUSINESS PLC
摘要:The present invention relates to sulfonium salts of formula (I): (I), their preparation, and utility as precursors for preparing functionalized organic compounds, wherein R 1 and R 2 are the same or different and each is independently selected from an optionally substituted aryl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted cycloalkenyl group, an optionally substituted aralkyl group, an optionally substituted arylalkenyl group, an optionally substituted heteroaryl group, an optionally substituted heterocyclyl group, an optionally substituted amine, an optionally substituted alkoxy group, an optionally substituted thioether group, an optionally substituted phosphine group, an optionally substituted boron species, an optionally substituted carbene, an organometallic moiety, and a halide, or R 1 and R 2 are joined together to form an optionally substituted sulfur-containing ring; W is a bond, an optionally substituted alkynylene group, an optionally substituted alkenylene group, and optionally substituted alkylene group, an optionally substituted heterocyclyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group; R 3 is a moiety comprising at least one basic group, provided that when R 3 does not contain any carbon atoms, W is not a bond; X is an anionic species; and n is an integer selected from 1 to 5.