专利号:WO-03031376-A1 优先权日:2001-10-12 标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one 发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.
专利号:US-8742028-B2 优先权日:2009-05-06 标 题:Solid support for Fmoc-solid phase synthesis of peptide acids 发明人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R 权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC 摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
专利号:WO-2015179088-A1 优先权日:2014-05-22 标题 :Conversion of 5-(halomethyl)-2-furaldehyde into polyesters of 5-methyl-2furoic acid 发明人:CAHANA AVIAD; MARTIN TIMOTHY J; GEORGE TIMOTHY R 权利人:XF TECHNOLOGIES INC 摘要:The present invention provides methods of synthesis of di-, tri-, and poly- ester derivatives of 5- methyl-2-furoic acid; di-, tri-, and poly- amide derivatives of 5-methyl-2-furoic acid; and di-, tri-, and poly- thioester derivatives of 5-methyl-2-furoic acid from 5-(halomethyl)-2-furaldehydes. These molecules are useful as plasticizers, solvents, coalescers, an ingredient in plastisol compositions, diluents, an ingredient in adhesive compositions, compatibilizer or compounding agent, or lubricant, as well as polymer compositions containing such ester compositions.
专利号:US-10550087-B2 优先权日:2015-11-17 标 题:Process for the preparation of kinase inhibitors and intermediates thereof 发明人:STURDIVANT JILL MARIE; DELONG MITCHELL A; CHAMBOURNIER GILLES; PAMMENT MICHAEL G; FEDIJ VICTOR 权利人:AERIE PHARMACEUTICALS INC 摘要:Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.
专利号:US-9643927-B1 优先权日:2015-11-17 标题:Process for the preparation of kinase inhibitors and intermediates thereof 发明人:STURDIVANT JILL M; DELONG MITCHELL A; CHAMBOURNIER GILLES; PAMMENT MICHAEL G; FEDIJ VICTOR 权利人:AERIE PHARMACEUTICALS INC 摘要:Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.
专利号:US-2024400552-A1 优先权日:2016-11-11 标题 :Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
[参考文献]: Bi Yunmei, Et Al. [参考文献]: Zhong Yao Cai. 2004 Apr;27(4):270-2. [参考文献]: Radosaw Swiercz, Et Al. Toxicokinetics And Metabolism Of Pseudocumene (1,2,4-Trimethylbenzene) After Inhalation Exposure In Rats. Int J Occup Med Environ Health. 2002;15(1):37-42.
合成参考文献
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