CAS: 62-38-4; Phenylmercury Acetate

该化合物是一种有机汞化合物,其化学配方为C9H9HGO2.它看起来像一种白色晶状固体,以其在各种应用中,特别是在农业和制药中用作杀真菌剂和防腐剂而闻名.该化合物的特点是附于汞原子的一个联苯组,该原子进一步与乙酸酯组结合.这一结构有助于其生物活动,因为汞可以干扰细胞过程.苯乙烯乙酸酯在有机溶剂中溶解,但水溶性有限.由于其含汞含量,它可能构成健康和环境风险,导致对其使用进行监管检查和限制.在处理该化合物时,安全防范至关重要,因为汞有毒,可在活生物体中积累.

结构式图片

MSDS等安全信息

欧盟法规

《欧盟PIC法规》统一分类与标签ECHA物质欧盟化妆品法规附录五-准用防腐剂清单ECHA物质工作场所安全标识要求OtherC&L通报REACH预注册欧盟限制物质清单废弃物危险特性清单

上下游产品

CAS号368-47-8 苯基三氟硅烷 | CAS号1600-27-7 乙酸汞 | CAS号383-35-7 ethyldifluoroph... | CAS号71-43-2 苯 | CAS号328-57-4 difluoro-methyl... | CAS号1125-27-5 乙基苯基二氯硅烷 | CAS号631-60-7 乙酸亚汞 | CAS号94-36-0 过氧化苯甲酰 | CAS号64-19-7 冰醋酸 | CAS号143-66-8 四苯硼钠 | CAS号94-50-8 苯甲酸辛酯 | CAS号19980-46-2 (Z)-α-Methylsty... | CAS号19980-44-0 acetic acid,1-p... | CAS号14371-10-9 桂皮醛 | CAS号104-53-0 3-苯丙醛 | CAS号462-06-6 氟苯 | CAS号300-57-2 烯丙基苯 | CAS号3412-44-0 trans-β-benzyls... | CAS号2550-26-7 4-苯基-2-丁酮 | CAS号1896-62-4 反式苯亚甲基丙酮

合成工艺路线路线简述

    Methyldifluorophenylsilane置于mercury(II) Diacetate体系中,用 苯 作为反应溶剂,以20%的收率获得产物乙酸苯汞
    参考文献:Nucleophilic Cleavage Of The Sic Bond In Organotrifluorosilanes And Diorganodifluorosilanes
    标题:Nucleophilic Cleavage Of The Sic Bond In Organotrifluorosilanes And Diorganodifluorosilanes
    摘要:
    DOI:10.1016/0022-328X(88)89077-6

    海关参考信息

    专利信息


    专利号:US-10793495-B2
    优先权日:2015-08-14
    标 题:Synthesis of polyaryl substituted aryl compounds
    发明人:BOULOS RAMIZ; FEUTRILL JOHN
    权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD
    摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)

    专利号:US-10022366-B2
    优先权日:2013-04-23
    标 题:Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
    发明人:STINCHCOMB AUDRA L; GHOSH PRIYANKA
    权利人:STINCHCOMB AUDRA L; GHOSH PRIYANKA; UNIV MARYLAND; UNIV KENTUCKY RES FOUND
    摘要:Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.

    专利号:US-8735391-B2
    优先权日:2008-09-26
    标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods
    发明人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J
    权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS
    摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.

    专利号:WO-2024256370-A1
    优先权日:2023-06-13
    标 题 :Synthesis of glufosinate using an amidase-based process
    发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

    专利号:WO-2021250635-A1
    优先权日:2020-06-11
    标题:Acid salts of fluoroquinolone carboxylic acid based compositions and methods of making and using the same
    发明人:GHOSH SUMANA; BHATTACHARYYA ANAMIKA; SINGH HIMANSHI; SADHASIVAM SURESH; SINHA MAU; GARG MUKESH KUMAR; GARKHAL KALPNA; KUMAR MUKESH; KHARE PRAGATI; GUPTA SWATI; SENGUPTA SHILADITYA; CHAVDARIAN CHARLES G
    权利人:VYOME THERAPEUTICS INC
    摘要:The present disclosure is in the field of pharmaceutical and chemical sciences. The present disclosure generally relates to the synthesis of therapeutic agents, processes for preparing said agents, compositions comprising said therapeutic agents and their uses. In particular, the disclosure relates to medicinally important acid salts of fluoroquinolone carboxylic acid based chemical molecules [compounds of formula (I)], method of preparing said molecules, compositions thereof, and the use of such molecules as therapeutic agents. The said acid salts of fluoroquinolone carboxylic acid based chemical molecules are useful in treating infections such as ear infections, otitis, otitis media including acute otitis media, recurrent otitis media, otitis media with effusion, chronic otitis media, chronic suppurative otitis media, otitis externa (including acute otitis externa, chronic otitis externa), otitis interna and combinations thereof.

    专利号:US-2025120400-A1
    优先权日:2021-12-10
    标题:Synthesis of glufosinate using a hydantoinase-based process
    发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
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    主要参考文献


    1: LaVoie SP, Summers AO. Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure. BMC Genomics. 2018 Jan 16;19(1):52. doi: 10.1186/s12864-017-4413-z. Erratum in: BMC Genomics. 2018 Apr 18;19(1):268.
    2: Cabral L, Yu RQ, Crane S, Giovanella P, Barkay T, Camargo FA. Methylmercury degradation by Pseudomonas putida V1. Ecotoxicol Environ Saf. 2016 Aug;130:37-42. doi: 10.1016/j.ecoenv.2016.03.036. Epub 2016 Apr 8. doi: 10.7860/JCDR/2015/12181.6716. Epub 2015 Nov 1.
    4: LaVoie SP, Mapolelo DT, Cowart DM, Polacco BJ, Johnson MK, Scott RA, Miller SM, Summers AO. Organic and inorganic mercurials have distinct effects on cellular thiols, metal homeostasis, and Fe-binding proteins in Escherichia coli. J Biol Inorg Chem. 2015 Dec;20(8):1239-51. doi: 10.1007/s00775-015-1303-1. Epub 2015 Oct 26.

    合成参考文献


    摘要:Toho Igakkai Zasshi. Journal of Medical Society of Toho University., 9(101), 1962
    摘要:Archiv fuer Experimentelle Veterinaermedizin., 34(383), 1980 []
    摘要:Acta Medica Scandinavica., 143(365), 1952 []
    摘要:Toxicology and Applied Pharmacology., 2(344), 1960 []
    摘要:Acute Toxicity Data. Journal of the American College of Toxicology, Part B., 1(175), 1992
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