CAS: 7463-31-2; 3-Acetamidoacetophenone

上下游产品

CAS号108-24-7 乙酸酐 | CAS号99-03-6 3'-氨基苯乙酮 | CAS号75-36-5 乙酰氯 | CAS号64-19-7 冰醋酸 | CAS号98-86-2 苯乙酮 | CAS号121-89-1 3-硝基苯乙酮 | CAS号201230-82-2 carbon monoxide | CAS号5369-16-4 3-异丙基苯胺 | CAS号325715-13-7 N-(3-乙酰基苯基)-N-甲基乙酰胺 | CAS号30095-56-8 3-乙酰氨基-2-溴苯乙酮 | CAS号96605-66-2 N-乙基-N-3-[(3-二甲... | CAS号587-02-0 3-乙基苯胺 | CAS号159724-49-9 Ethanone,1-(2,3... | CAS号115931-01-6 N-[3-(3-氰基吡唑并[1... | CAS号16994-13-1 1-(5-氨基-2-硝基苯基)乙酮 | CAS号18640-60-3 1-(5-氯-2-硝基)苯乙酮 | CAS号7766-63-4 N-(3-propan-2-y...

苯乙酮置于硫酸,硝酸,铁粉体系中,化学反应 2.0H,反应生成 3-乙酰胺基苯乙酮
参考文献:一种合成扎莱普隆的新方法
标题:一种合成扎莱普隆的新方法
摘要:本发明提供了一种合成扎莱普隆的新方法.具体地,本发明方法以苯乙酮为原料,制得n-乙基-N-[3-(3-二甲基胺-1-氧代-2-丙烯基)苯基]乙酰胺,再与3-氨基-4-氰基吡唑反应,形成n-[3-(3-氰基吡唑并[1,5-α]嘧啶-7-基)苯基]-N-乙基乙酰胺.本发明的合成路线步骤少,后处理简单,成本低廉,适宜于产业化生产.

专利信息

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002165398-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimers disease and schizophrenia, and infectious diseases.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-7034154-B2
优先权日:1999-08-10
标 题:Synthesis of substituted pyrazolopyrimidines
发明人：GROSS RAYMOND S; WILCOXEN KEITH M; OGLESBY RICHARD CHRISTOPHER
权利人:NEUROCRINE BIOSCIENCES INC
摘要:Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and/or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.

专利号:US-7498434-B2
优先权日:2004-01-14
标题:Two-phase method for the synthesis of selected pyrazolopyrimidines
发明人：CANTRELL GARY LEE; MOSER FRANK WILLIAM; HALVACHS ROBERT EDWARD
权利人:MALLINCKRODT INC
摘要:An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.