CAS: 79-44-7; Dimethylcarbamoyl Chloride

上下游产品

CAS号137-26-8 二硫化四甲基秋兰姆 | CAS号2757-23-5 氯羰基亚磺酰氯 | CAS号124-40-3 二甲胺 | CAS号32315-10-9 三光气 | CAS号75-44-5 光气 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号88470-22-8 1-chloro-1-meth... | CAS号687-48-9 二甲基氨基甲酸乙酯 | CAS号3013-02-3 S-methyl N,N-di... | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号112143-82-5 唑蚜威 | CAS号1071-38-1 (二甲氨基亚甲基)二甲基氯化铵 | CAS号34123-59-6 异丙隆 | CAS号598-94-7 N,N-二甲基脲 | CAS号493-77-6 2,4,6-三苯基三嗪 | CAS号106932-30-3 methyl-4 phenyl... | CAS号330-54-1 敌草隆 | CAS号36057-44-0 4-甲氧基氰基砒啶 | CAS号333985-78-7 1-(二甲基氨基甲酰)哌啶-4-羧酸乙酯 | CAS号106932-28-9 2-Dimethylamino...

福美双置于氯,水,碳酸氢钠体系中,用 二氯甲烷 作为反应溶剂,化学反应 6.33H,以86.2%的收率获得产物二甲氨基甲酰氯
参考文献:开发一种将秋兰姆二硫化物转化为 N,N-二烷基氨基甲酰基卤化物和衍生物的改进方法
标题:开发一种将秋兰姆二硫化物转化为 N,N-二烷基氨基甲酰基卤化物和衍生物的改进方法
摘要:报道了一种制备 N,N-二取代氨基甲酰卤的简便方法.它由两个步骤组成:(1)二硫化碳和仲胺在极性有机溶剂和氧气存在下反应反应生成相应的四烷基秋兰姆二硫化物和(2)四烷基秋兰姆与卤化物在一种非质子有机溶剂,可产生相应的 N,N-二取代氨基甲酰卤.
DOI:10.1080/00397910903537331

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-8273790-B2
优先权日:2005-01-14
标 题:Exo-selective synthesis of himbacine analogs
发明人：THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-5512701-A
优先权日:1995-06-07
标题:Process for the synthesis of vinyl sulfenic acid derivatives
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.

专利号:US-2012203004-A1
优先权日:2009-08-13
标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors
发明人：ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA
权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD
摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.

专利号:US-8697876-B2
优先权日:2010-04-02
标 题:Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
发明人：CARNIAUX JEAN-FRANCOIS; CUMMINS JONATHAN
权利人:CARNIAUX JEAN-FRANCOIS; CUMMINS JONATHAN; COLUCID PHARMACEUTICALS INC
摘要:The present invention provides a novel polymorph of the hemisuccinate salt of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide (Form A) characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure. This polymorph is useful in pharmaceutical compositions, for example, for the treatment and prevention of migraine. The invention also provides a process for the synthesis of pyridinoylpiperidine compounds of Formula I in high yield and high purity. In particular, the provides a process for the preparation of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide, its hemisuccinate salt and polymorph (Form A).