CAS: 96036-03-2; (4R,5S,6S)-3-(((3S,5S)-5-(Dimethylcarbamoyl)Pyrrolidin-3-yl)Thio)-6-((R)-1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid

• 英文名称(4R,5S,6S)-3-(((3S,5S)-5-(Dimethylcarbamoyl)Pyrrolidin-3-yl)Thio)-6-((R)-1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
• 中文名称美罗培南
• IUPAC名称Meropenem
• 其它别名(4R,5S,6S)-3-[[(3S,5S)-5-Dimethylcarbamoylpyrrolidin-3-; (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)Pyrrolidin-3-Yl]Thio]-6-[(1R)-1-Hydroxyethyl]-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid; )-3-Pyrrolidinyl)Thio)-6-(1-Hydroxyethyl)-4-Methyl-7-Oxo-,(4R-(3(S*,5S*),4-Al; 5-Beta,6-Beta(R*)))-Ph; Meropenem, Usp Standard; Meropenam
• CAS编号96036-03-2
• MFCD编号:MFCD00864966
• EINECS号:641-424-1
• 分子式:C17H25N3O5S
• 分子量:383.47
• 产品CID: 2015938
• 同类组份化合物CAS96036-03-2 (free)119478-56-7 (hydrate)211238-34-5 (sodium)
• 产品分类原料药 → 抗生素类药物 → β→内酰胺酶抑制剂

• 相似结构搜索
• 产品信息参考
• InChIKey: DMJNNHOOLUXYBV-PQTSNVLCSA-N
• InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,…
• 计算化学: 氢键受体数7.0氢键供体数3.0可旋转键数5.0

物理性质

• 熔点191-201°C
• 沸点627.4±55.0 °C(预测)
• 闪点333.2 °C
• 密度1.42±0.1 g/cm3(预测)
• pKa:4.27±0.60(预测)
• PSA:135.48
• LogP:-0.0413
• 折射率1.639
• 蒸汽压2.27E-18 mmHg at 25 °C
• 溶解性Insoluble In Etoh; ≥19.15 mg/mL In DMSO; ≥9.88 mg/mL In H2O With Ultrasonic
• 外观形态白色至类白色固体
• 储存条件密封干燥,冷冻保存, 低于 -20°C
• 产品应用该化合物用作治疗易感染细菌感染的临床治疗广泛频谱卡巴匹宁抗生素,包括:1. 呼吸道感染(如慢性支气管炎,医院肺炎,肺炎和肺炎,肺炎);2. 腹部感染(例如胆固炎,脊髓炎,肝炎,肠炎,腹炎);3. 尿道和生殖道感染 (例如,双喉炎,复杂的细胞炎,内分泌炎,肾炎,急性炎,宫内感染,骨盆炎,麻风炎);4. 骨髓,联合,皮肤和软组织感染(诸如,细胞炎,皮炎,骨髓炎,骨髓血管炎,关节炎,动脉炎,节炎,创伤感染,烧伤性伤口感染,手术现场感染,人脑和半人脑细胞炎);5. 呼吸系统炎和脑炎;6. 膀胱膜炎成人的腹膜疗法;6. 作为膀胱阴道感染的脑疗法;6 作为膀状腺感染的成人的脑膜疗法.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别呼吸道致敏 类别1
  皮肤致敏 类别1
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
  H317 |可能引起皮肤过敏反应.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
• 危险品标志Xi
• 安全声明26-37/39
• 危险类别码36/37/38

欧盟法规

上下游产品

合成工艺路线路线简述

• 115295-90-4 = 96036-03-2
  反应条件:1.1 Reagents: Tributylstannane Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Dichloromethane,Ethyl Acetate; 30 °C; 3 H,Rt
  标题:Method For Synthesis Of Meropenem
  参考文献:World Intellectual Property Organization]
  
  96036-02-1 = 96036-03-2
  反应条件:1.1 Reagents: Formic Acid Catalysts: Palladium Solvents: Tetrahydrofuran,Water; Ph 7.5,Rt -> 10 °C; 10 °C; 4.5 H,10 °C
  标题:Method For Preparation Of Meropenem With High Purity
  参考文献:China]
  
  90776-59-3 + 1516884-94-8 = 96036-03-2
  反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Dimethylformamide,Tetrahydrofuran; 5 H,-40 °C1.2 Reagents: Hydrogen Catalysts: Palladium; 1 H,20 °C
  标题:One-Pot Method For Preparation Of Meropenem
  参考文献:China]
  
  936226-35-6 = 96036-03-2
  反应条件:1.1 Reagents: 3,5-Dimethylpyridine,Hydrogen Catalysts: Palladium Solvents: Tetrahydrofuran,Water; 6 H,Rt
  标题:Meropenem Bulk Drug,Preparation Method And Pharmaceutical Composition
  参考文献:China]
  
  96036-02-1 = 96036-03-2
  反应条件:1.1 Catalysts: Palladium Solvents: Tetrahydrofuran,Water; 6 H,Rt
  标题:Meropenem Bulk Drug,Preparation Method And Pharmaceutical Composition Containing Same
  参考文献:China]
  
  171890-81-6 = 96036-03-2
  反应条件:1.1 Reagents: Trifluoroacetic Acid,P-Toluenesulfonic Acid Solvents: Dichloromethane; 1 H,Rt; 5 H,Rt
  标题:Method For Preparing Meropenem From Carbapenem Bicyclic Nucleus And (2S,4S)-2-(Dimethylaminocarbonyl)-4-Mercapto-1-(P-Nitrobenzyloxycarbonyl)-1-Pyrrolidine
  参考文献:China]
  
  96036-02-1 = 96036-03-2
  反应条件:1.1 Reagents: 1-Methylpyrrolidine Catalysts: Palladium (Carbon Supported Pd Catalyst) Solvents: Tetrahydrofuran,Water; 25 °C
  标题:Continuous Reaction Device For Preparing Meropenem And Its Preparation Method
  参考文献:China]
  
  96036-02-1 = 96036-03-2
  反应条件:1.1 Reagents: 4-Methylaniline,Hydrogen Catalysts: Platinum; 41 Min,18 Bar,25 °C
  标题:Process For The Deprotection Of A Carbapenem By Heterogeneous Catalytic Hydrogenation With Hydrogen In The Presence Of An Organic Amine
  参考文献:World Intellectual Property Organization]
  
  936226-35-6 = 96036-03-2
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Tetrahydrofuran,Water; 90 S,1.4 Mpa,80 °C
  标题:Method For Preparing Pharmaceutical Meropenem And Intermediate 10,11-Dihydro-5H-Dibenzo[b,F]Azepine By Continuous Solid-Liquid-Gas Three-Phase Reaction
  参考文献:China]
  
  96036-02-1 = 96036-03-2
  反应条件:1.1 Reagents: Morpholine,Hydrogen Catalysts: Palladium Dihydroxide Solvents: Tetrahydrofuran,Water; Ph 7; 6 H,Ph 7,5 Kg/cm2,Rt1.2 Solvents: Acetone,Water; Overnight,0 - 5 °C
  标题:Method For The Preparation Of Carbapenem Compound
  参考文献:Korea

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2905122000-异丙醇
  2912110000-甲醛
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管