合成目标产物 Diethylenetriaminepenta(Methylene-Phosphonic Acid) 主要起始原料 Formaldehyde And Diethylenetriamine
(文献来源)合成步骤主要原料 Formaldehyde 和 Diethylenetriamine
二乙烯三胺五醋酸置于phosphorus(III) Oxide,甲烷磺酸体系中,化学反应 2.0H,以89.6%的收率获得二乙烯三胺五甲叉膦酸 参考文献: Method For The Synthesis Of Alpha-Aminoalkylenephosphonic Acid[fr] Procédé De Synthèse D'Acide Alpha-Aminoalkylènephosphonique 标题: Method For The Synthesis Of Alpha-Aminoalkylenephosphonic Acid[fr] Procédé De Synthèse D'Acide Alpha-Aminoalkylènephosphonique 摘要:本发明涉及一种合成α-氨基烯基膦酸或其膦酸酯的新方法,包括以下步骤:通过混合含有一个p原子在氧化态(+111)和另一个p原子在氧化态(+111)或(+v)的p-O-P酸酐基团的化合物,氨基烷基羧酸和酸催化剂来形成反应混合物,其中所述反应混合物中α-氨基烯基羧酸与p-O-P酸酐基团的当量比至少为0.2,并从反应混合物中回收所得的α-氨基烯基膦酸化合物或其酯.
专利号:US-10280189-B2 优先权日:2012-07-17 标题:Method for the synthesis of aminoalkylenephosphonic acid 发明人:BURCK SEBASTIAN; LECLERCQ CEDRIC NICOLAS; NOTTE PATRICK 权利人:MONSANTO TECHNOLOGY LLC 摘要:A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR 1 R 2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.
专利号:US-2004044225-A1 优先权日:2001-06-01 标 题:Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives 发明人:KANTER JAMES; MARLOWE CHARLES; PANDEY ANJALI; MULLINS JOHN J G; SCARBOROUGH ROBERT; BUTKE GREG; JACOBSON BARRY; WALKER DEREK 摘要:Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.
专利号:US-2024309142-A1 优先权日:2023-03-17 标题 :Capped block copolymers, their synthesis, manufacture, and methods of use 发明人:MAN VICTOR FUK-PONG; LI XIAOJIN HARRY; CHEN YIQING; PU GANG; HUNT JR CLINTON 权利人:ECOLAB USA INC 摘要:This disclosure relates to capped block copolymers, preferably reverse block copolymers capped with a hydrophobic group. Preferred hydrophobic groups include benzyl groups and silyl groups. In a preferred embodiment, the reverse block copolymer has at least two arms, wherein each arm is capped with a hydrophobic group. The disclosure also provides for the synthesis of the capped block copolymers as well as methods of using the capped block copolymers for defoaming and antifoaming applications.
专利号:US-8147805-B2 优先权日:2005-01-05 标题:Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications 发明人:YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND 权利人:YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND; UNIV T EXAS SYSTEM BOARD OF REGENTS 摘要:Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X 1 —Y—X 2 , wherein Y comprises two or more carbohydrate residues covalently attached to one another, X 1 and X 2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X 1 and X 2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.
专利号:US-2016293932-A1 优先权日:2015-03-30 标题 :Synthetic methods for transition metal coordination compounds 发明人:MOTALLEBI SHAHROKH; RISSET OLIVIA NATHALIE; WESSELLS COLIN DEANE 权利人:ALVEO ENERGY INC 摘要:A system and method for controlling particle morphology of transition metal coordination compounds (TMCC). Synthesis of TMCC using one of several chelating agents having carboxylate chemical groups. These carboxylate groups bind to copper during the synthesis of the CuHCF TMCC materials, resulting in controlled particle growth, rather than rapid formation of many small nanoparticles as is the case without any chelating agent present. The materials produced using chelating agents of these embodiments such as these are composed of larger particles, making them easier to process into battery electrodes via standard methods such as slurry mixing and coating. The resulting electrodes retain the good electrochemical cycling performance of the control material synthesized without a chelating agent.
专利号:US-2007196275-A1 优先权日:2001-04-26 标题 :Diagnostic Imaging Compositions, Their Methods Of Synthesis And Use 发明人:LI CHUN; WEN XIAOXIA; WU QING-PING; WALLACE SIDNEY; ELLIS LEE M 权利人:LI CHUN; WEN XIAOXIA; WU QING-PING; WALLACE SIDNEY; ELLIS LEE M 摘要:Conjugate molecules comprising a ligand bonded to a polymer are disclosed. One such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer-chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.
参考标题: Method For The Synthesis Of Aminoalkylenephosphonic Acid Procédé De Synthèse D'Acide Aminoalkylènephosphonique 摘要:The Present Invention Is Related To A Method For The Synthesis Of An Aminoalkylenephosphonic Acid Or Its Phosphonate Esters Comprising The Following Steps: A) Forming, In The Presence Of An Aldehyde Or Ketone And An Acid Catalyst, A Reaction Mixture By Mixing A Compound Comprising At Least One Hnr1R2 Moiety Or A Salt Thereof, With A Compound Having One Or More P-O-P Anhydride Moieties, Said Moieties Comprising One P Atom At The Oxidation State (+iii) And One P Atom At The Oxidation State (+iii) Or (+v), Wherein The Ratio Of Moles Of Aldehyde Or Ketone To N-H Moieties Is 1 Or More And Wherein The Ratio Of N-H Moieties To P-O-P Anhydride Moieties Is 0.3 Or More And, B) Recovering The Resulting Aminoalkylenephosphonic Acid Comprising Compound Or Its Phosphonate Esters.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118