CAS: 312756-74-4; 3-(N-Benzylsulfamoyl)-4-Bromo-N-(4-Bromophenyl)Benzamide

上下游产品

4-Bromobenzoic acid 3-benzylsulfamoyl-4-bromobenzoic acid 4-bromo-aniline

4-溴苯甲酸置于氯磺酸,草酰氯体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 28.25H,反应生成 4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺
参考文献: Methods Of Treating Cancer Using Rad51Small Molecule Stimulators[fr] Procédés De Traitement Du Cancer à L'Aide De Stimulateurs De Molécules Rad51Small
标题: Methods Of Treating Cancer Using Rad51Small Molecule Stimulators[fr] Procédés De Traitement Du Cancer à L'Aide De Stimulateurs De Molécules Rad51Small
摘要:通过给予刺激rad51活性的化合物来杀死或抑制癌细胞和肿瘤的生长,并治疗癌症的方法.过度表达rad51或在同源重组机制中存在其他不平衡的细胞特别容易成为rad51刺激剂的靶点.

专利信息

专利号:US-12416015-B2
优先权日:2017-09-15
标题:Multiplex production and barcoding of genetically engineered cells
发明人：ROY KEVIN; SMITH JUSTIN D; ST ONGE ROBERT P; STEINMETZ LARS M; HABER JAMES E
权利人:UNIV LELAND STANFORD JUNIOR; UNIV BRANDEIS
摘要:The present disclosure relates to multiplex production and phenotyping of genetically engineered cells using RNA-guided nucleases and genomic barcoding. In particular, high-throughput multiplex genome editing is achieved utilizing a system that facilitates precise genome editing at desired target chromosomal loci by homology directed repair. Integration of guide RNA and donor DNA sequences as a genomic barcode at a separate chromosomal locus allows identification, isolation, and massively-parallel validation of individual variants from a pool of transformants. Strains can be arrayed according to their precise genetic modifications, as specified by donor DNA incorporation in heterologous or native genes. The present disclosure further relates to a method of editing codons outside of canonical guide RNA recognition regions, which enables complete saturation mutagenesis of protein-coding genes, a marker-based internal cloning method, which removes background due to oligonucleotide synthesis errors and incomplete vector backbone cleavage, and a method of enhancing homology directed repair by active donor recruitment.

专利号:CN-113333017-B
优先权日:2021-05-18
标 题 :Preparation method and application of a biochar-assisted synthesis of bifunctional catalysts