CAS: 4546-55-8; N6-Benzoyladenosine

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CAS号98-88-4 苯甲酰氯 | CAS号58-61-7 腺苷 | CAS号14686-89-6 二丙酮-D-葡萄糖 | CAS号22331-21-1 3-O-苄基-1,2:5,6-... | CAS号118684-36-9 O2,,O3',O5'-tri... | CAS号610305-23-2 O2,,O3',O5'-tri... | CAS号4754-39-6 5'-脱氧腺苷 | CAS号5135-30-8 5'-对甲苯磺酸腺苷 | CAS号613-90-1 苯甲酰腈 | CAS号13116-38-6 2-(6-aminopurin... | CAS号14365-44-7 5-氨基腺苷酸 | CAS号737-76-8 Adenosine,5'-az... | CAS号76902-49-3 N6-BENZOYL-3'-D...

腺苷置于ammonium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应生成 N6-苯甲酰基腺苷
参考文献:由腺苷和鸟苷有效合成受保护的3'-脱氧腺苷和3'-脱氧鸟苷
标题:由腺苷和鸟苷有效合成受保护的3'-脱氧腺苷和3'-脱氧鸟苷
摘要:描述了由腺苷和鸟苷高效合成保护的3'-脱氧腺苷和3'-脱氧鸟苷.2',3'-二醇保护的腺苷和鸟苷,用α-乙酰氧基异丁酰溴反应,得到9-(2'-ø-乙酰基3'-溴-5'-ø-叔-Butyldiphenylsilyl-3'-脱氧-β-D呋喃木糖基)-6-ñ-苯甲酰基腺嘌呤和9-(2'-ø-乙酰基3'-溴-5'-ø-叔-Butyldiphenylsilyl-3'-脱氧-β-D呋喃木糖基)-2-ñ-(ñ ',ñ '-Dimethylaminomethylene)鸟嘌呤,随后用三-加热ñ-丁基氢化锡在2,2'-偶氮二异丁腈的存在下,以全部收率提供66-73%的受保护的3'-脱氧腺苷和3'-脱氧鸟苷.
DOI:10.1016/s0040-4039(00)02041-4

专利信息

专利号:US-9512162-B2
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9493773-B2
优先权日:2012-07-31
标题:Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9365607-B1
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9045521-B2
优先权日:2012-07-31
标 题 :Synthesis of deuterated ribo nucleosides N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:SRIVASTAVA SURESH C; YASKO AMY; ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:WO-2024082545-A1
优先权日:2022-10-21
标 题:Method for enzymatic synthesis of nucleoside containing protecting group, and composition
发明人：HONG HAO; JAMES GAGE; XIAO YI; ZHANG NA; JIAO XUECHENG; LI MINGJI; LI RUI; DING SHIMAO
权利人:ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
摘要:The present invention provides a method for enzymatic synthesis of a nucleoside containing a protecting group, and a composition. The method comprises: using pyrimidine nucleoside phosphorylase or uracil nucleoside phosphorylase and purine nucleoside phosphorylase to catalyze a substrate to synthesize a nucleoside containing a protecting group, wherein the substrate comprises a substrate nucleoside, a substrate base and a substrate phosphate, and the substrate base contains a protecting group; the pyrimidine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PyNP shown in SEQ ID NO: 1; the uracil nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein UP shown in SEQ ID NO: 2; and the purine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PNP shown in SEQ ID NO: 3, 7 or 8. The present invention can solve the problem in the prior art that there is no biosynthesis method to produce a nucleoside containing a protecting group, and is suitable for the field of enzyme catalysis.

专利号:US-11897914-B2
优先权日:2021-11-29
标题 :Synthesis of 2′ protected nucleosides
发明人：POON WING C; ZOU RUIMING; LAU ALDRICH N K; YU DAVID; Du Gengyu; YAO YUN-CHIAO; ZHAO GANG
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.