CAS: 463-71-8; Thiophosgene

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CAS号594-42-3 全氯甲硫醇 | CAS号56-23-5 四氯化碳 | CAS号75-44-5 光气 | CAS号7783-06-4 硫化氢 | CAS号1540-72-3 2,2-dichloro-4,... | CAS号75-15-0 二硫化碳 | CAS号7782-50-5 氯气 | CAS号556-64-9 硫氰酸甲酯 | CAS号10026-13-8 五氯化磷 | CAS号7647-01-0 盐酸 | CAS号10506-37-3 硫代氯甲酸-2-萘酯 | CAS号109343-21-7 3-Thiophenecarb... | CAS号109029-20-1 3-isothi°Cyanat... | CAS号109960-13-6 N-butan-2-yl-1-... | CAS号107743-39-5 7-diethylamino-... | CAS号583-39-1 2-巯基苯并咪唑 | CAS号3529-87-1 4-苯氧基苯基异硫氰酸酯 | CAS号33522-03-1 环戊基异硫氰酸酯 | CAS号3550-21-8 二苯甲基异硫氰酸盐 | CAS号3137-84-6 3-乙氧基羰基苯异硫氰酸酯

光气 反应生成 硫光气
参考文献:3-(1,2-Benzisothiazol-And Isoxazol-5-Y1)-2,4(1H,3H)-Pyrimidinedione Or Thione And 3-(1,2-Benzisothiazol-And Isoxazol-5-Y1)-4(3H)-Pyrimidinone Or Thione Herbicidal Agents
标题:3-(1,2-Benzisothiazol-And Isoxazol-5-Y1)-2,4(1H,3H)-Pyrimidinedione Or Thione And 3-(1,2-Benzisothiazol-And Isoxazol-5-Y1)-4(3H)-Pyrimidinone Or Thione Herbicidal Agents

专利信息

专利号:US-9446995-B2
优先权日:2012-05-21
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-6207858-B1
优先权日:1999-03-03
标 题 :Regioselective synthesis of DTPA derivatives
发明人：CHINN PAUL; GYORKOS ALBERT; LABARRE MICHAEL J; RUHL STEVE; RYSKAMP THOMAS
权利人:IDEC PHARMA CORP
摘要:The present invention provides a process for high yield regioselective synthesis of DTPA derivatives that eliminates the need for ion exchange chromotographic separation of intermediates. Moreover, as this process yields a single regioisomer of the chelate, it provides for the regiospecific synthesis of desired chelates useful as radiolabeling agents.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-8835477-B2
优先权日:2009-10-06
标题 :Method for the synthesis of 2-thiohistidine and the like
发明人：ERDELMEIER IRÈNE; DAUNAY SYLVAIN
权利人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN; TETRAHEDRON
摘要:Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.