CAS: 50-28-2; Estradiol

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专利信息

专利号:US-6448419-B1
优先权日:2001-08-07
标题:Synthesis of 2-hydroxyestradiol derivatives
发明人：PAAREN HERBERT E; DUFF STEVEN R
权利人:TETRIONICS INC
摘要:Disclosed is a method of preparing 2-hydroxy-3,17β-estradiol derivatives wherein 3,17β-estradiol is reacted with an organolithium reagent and reacted with either a boron reagent or a silicon reagent to form either a 2-boronyl or a 2-silyl modified estradiol analog represented by the corresponding structural formulae: n R 1 and R 2 are each independently a hydroxyl protecting group. R 3 , R 4 and R 5 are selected from the group consisting of halogens, alkyl, aryl, hydroxy, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl.

专利号:US-6054598-A
优先权日:1997-03-13
标题 :Synthesis of 2-alkoxyestradiols
发明人：SACHDEVA YESH; RAM SIYA
权利人:PHARM ECO LAB INC
摘要:Disclosed is a method of preparing a compound represented by the following structural formula: The method comprises reacting bromine (Br2) and an aliphatic organic acid with a compound represented by the following structural formula: R1 and R2 are each independently a hydroxyl protecting group.

专利号:US-6051726-A
优先权日:1997-03-13
标 题 :Synthesis of 2-alkoxyestradiols