CAS: 66108-95-0; N1,N3-Bis(2,3-Dihydroxypropyl)-5-(N-(2,3-Dihydroxypropyl)Acetamido)-2,4,6-Triiodoisophthalamide

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CAS号31127-80-7 5-乙酰氨基-N,N'-双(2... | CAS号106-89-8 环氧氯丙烷 | CAS号96-24-2 3-氯-1,2-丙二醇 | CAS号556-52-5 缩水甘油 | CAS号71-36-3 正丁醇 | CAS号31127-80-7 5-乙酰氨基-N,N'-双(2...

5-硝基-N,N'-双(2,3-二羟基丙基)-1,3-苯二甲酰胺置于硫酸,5%-Palladium/activated Carbon,水,氢气,一氯化碘,Sodium Hydroxide体系中,用 乙二醇二甲醚,水 作为反应溶剂,20.0~100.0 °C,1.2 Mpa 条件下,反应 6.0H,反应生成 碘海醇
参考文献:碘海醇杂质f的合成方法及其在碘海醇杂质g,杂质h和杂质m合成中的应用
标题:碘海醇杂质f的合成方法及其在碘海醇杂质g,杂质h和杂质m合成中的应用
摘要:本发明涉及一种碘海醇杂质的合成方法,特别涉及一种碘海醇杂质f的合成方法及其在碘海醇杂质g,杂质h和杂质m合成中的应用,属于医药技术领域.该方法是以5‑硝基‑1,3‑苯二甲酸二甲酯(式2化合物)和2,3‑二羟基丙胺为原料制备式3化合物,式3化合物与氢气还原反应制得式4化合物,式4化合物再与一氯化碘反应得到碘海醇杂质f.本发明以5‑硝基‑1,3‑苯二甲酸二甲酯(式2化合物)为起始原料,合成5‑氨基‑n,N'‑双(2,3‑二羟基丙基)‑二碘‑1,3‑苯二甲酰胺(式1化合物)再以化合物式1为起始原料合成杂质g,杂质h和杂质m,为碘海醇质量控制提供合格的杂质对照品.

专利信息

专利号:US-8969619-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in propyleneglycol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.

专利号:US-12018313-B2
优先权日:2016-12-28
标题:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles
发明人：EMBREE MALLORY
权利人:NATIVE MICROBIALS INC
摘要:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-8962886-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in methanol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.

专利号:US-8962887-B2
优先权日:2009-07-21
标题 :Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
发明人：HOMESTAD OLE MAGNE
权利人:HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.

专利号:US-9549995-B2
优先权日:2012-03-26
标 题:Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy
发明人：YANG DAVID J; YU DONG-FANG
权利人:UNIV TEXAS
摘要:Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.