CAS: 695-95-4; Methyl 3-Oxocyclobutanecarboxylate

相似化合物

183616-18-4 63485-51-8 63485-50-7

上下游产品

CAS号67-56-1 甲醇 | CAS号23761-23-1 3-氧代环丁烷羧酸 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号15963-40-3 3-亚甲基环丁烷羧酸甲酯 | CAS号15760-35-7 3-亚甲基环丁基甲腈 | CAS号15760-36-8 3-亚甲基环丁烷羧酸 | CAS号183616-18-4 3-(羟甲基)-环丁酮 | CAS号98231-07-3 3,3-二甲氧基环丁烷羧酸甲酯 | CAS号545882-60-8 5,8-二氧螺[3.4]辛烷-2-甲醇

3-氧代环丁烷基羧酸置于甲醇,硫酸体系中,用 水 作为反应溶剂,以92.2%的收率获得产物3-氧代环丁烷甲酸甲酯
参考文献:取代的杂芳基化合物及其组合物和用途
标题:取代的杂芳基化合物及其组合物和用途
摘要:本发明提供了取代的杂芳基化合物及其组合物和用途.所述化合物为式(I)所示的化合物或者式(I)所示化合物的立体异构体,互变异构体,氮氧化物,溶剂化物,代谢产物,药学上可接受的盐或它的前药.本发明还提供了包含所述化合物的药物组合物,所述药物组合物可以调节蛋白激酶,尤其是aurora激酶和jak激酶的活性,用于预防,处理,治疗和减轻蛋白激酶,尤其是aurora激酶和jak激酶活性介导的疾病或紊乱.

专利信息

专利号:US-9738679-B2
优先权日:2013-03-15
标 题:Methods of synthesizing substituted purine compounds
发明人：OLHAVA EDWARD JAMES
权利人:EPIZYME INC
摘要:The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also provides novel crystalline forms of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof (Form A, Form B, and Form C), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.

专利号:CN-114560801-A
优先权日:2022-02-20
标题 :Method for photocatalytic synthesis of 3-cyanoalkyl-4-pyrroline-2-one and derivatives thereof

专利号:CN-116813529-A
优先权日:2023-07-03
标 题:Synthesis method of 6-tert-butoxycarbonyl-2-amino-6-azaspiro[3.4]octane

专利号:CN-108129288-B
优先权日:2017-12-27
标 题 :Synthesis method of trans-3-hydroxycyclobutylformic acid