CAS: 119-56-2; 4-Chlorobenzhydrol

上下游产品

4-chlorobenzaldehyde benzaldehyde 4-chlorophenylmagnesium iodide sodium isopropylate (+/-)-phthalic acid mono-(4-chloro-benzhydryl ester) p-chlorophenyl(phenyl)methyl p-tolyl sulfone (+/-)-[2-(4-chloro-benzhydryloxy)-ethyl]-dimethyl-amine 1-chloro-4-(chloro(phenyl)methyl)benzene

4-苄氧基氯苯置于叔丁基锂,氘代甲醇-D,水体系中,用 四氢呋喃,正戊烷 用作溶剂,化学反应 0.75H,反应生成4-氯二苯甲醇
参考文献:探索α-锂化的芳基苄基醚的反应性:抑制[1,2]-Wittig重排和机理建议
标题:探索α-锂化的芳基苄基醚的反应性:抑制[1,2]-Wittig重排和机理建议
摘要:通过仔细控制反应温度,用t Buli处理芳基苄基醚有选择地导致α-锂化,生成稳定的有机锂,这些有机锂可以在被预期的[1,2]-Wittig吸附之前直接被多种选择的亲电试剂捕获.重排.这种重排已在实验和计算上进行了深入研究,使用了在芳基环上带有不同取代基的芳基α锂化苄基醚.获得的结果支持了协同的阴离子分子内添加/消除序列和自由基解离/重组序列的能力,用于解释芳基迁移的趋势.对于具有有利于阴离子途径的电子贫芳基的底物,发现了更有利的重排.
Doi:10.1002/chem.201602254

专利信息

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:CN-1620295-A
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides

专利号:CA-2470202-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides

专利号:KR-20040101991-A
优先权日:2001-12-14
标题:Preparation of intermediates useful in the synthesis of antiviral nucleosides

专利号:CN-109053754-B
优先权日:2018-08-15
标 题:Synthesis of polysubstituted chroman compounds based on dearomatization cycloaddition strategy of biomass-derived 2,5-dimethylfuran

专利号:CN-111100851-A
优先权日:2018-10-25
标 题:Alcohol dehydrogenase mutant and application thereof in synthesis of chiral diaryl alcohol compound