专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
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合成参考文献
参考文献:10.1007/s11104-026-08436-4 摘要:Liu W, Chen X, Yang W, Dong D, Xu Y, Ye Z, Liu D, Wang M, Ma J. Bacillus megaterium-based bio-organic fertilizer improves tea quality by enhancing the biosynthesis of flavonoids and amino acids in tea. Plant Soil. 2026 Mar 03;(). doi: 10.1007/s11104-026-08436-4.