CAS: 163521-12-8; Vilazodone

上下游产品

Vilazodone N-Oxide 1637223-09-6
5-(4-(4-(5-氰基-1H-吲哚-3-基)丁基)哌嗪-1-基)苯并呋喃-2-羧酸 5-(4-(4-(5-Cyano-1H-Indol-3-yl)Butyl)Piperazin-1-yl)Benzofuran-2-Carboxylic Acid 163521-19-5
Methyl 5-{4-[4-(5-Cyano-1H-Indol-3-yl)-Butyl]-Piperazin-1-Yl}-Benzofuran-2-Carboxylate 1236722-93-2
5-[4-[4-(5-氰基-1H-吲哚-3-基)丁基]-1-哌嗪]-2-苯并呋喃羧酸乙酯 5-(4-[4-(5-Cyano-3-Indolyl)Butyl]-1-Piperazinyl)Benzofuran-2-Carboxylic Acid Ethyl Ester 163521-11-7
Methyl 5-{4-[4-(5-Cyano-1H-Indole-3-yl)-4-Hydroxybutyl]Piperazin-1-Yl}Benzofuran-2-Carboxylate 1451194-35-6
5-[4-[4-[5-Cyano-1-(Phenylsulfonyl)-1H-Indol-3-Yl]Butyl]Piperazin-1-Yl]Benzofuran-2-Carboxamide
5-[4-[4-[5-Cyano-1-(Naphthalene-2-Yl-Sulfonyl)-1H-Indol-3-Yl]Butyl]Piperazin-1-Yl]-2-Benzofurancarboxamide
5-[4-[4-[5-Cyano-1-(Naphthalen-1-Yl-Sulfonyl)-1H-Indol-3-Yl]Butyl]Piperazin-1-Yl]-2-Benzofurancarboxamide Methyl 5-{4-[(E)-4-(5-Cyano-1H-Indol-3-yl)-But-3-Enyl]-Piperazin-1-Yl}-Benzofuran-2-Carboxylate 5-[4-[4-[5-Cyano-1-(Phenylsulfonyl)-1H-Indol-3-Yl]Butyl]Piperazin-1-Yl]Benzofuran-2-Carboxylic Acid Ethyl Ester

在 Potassium Carbonate,Sodium Methylate,Formamide体系中,用 二氯甲烷,四氢呋喃 用作溶剂,以90%的收率获得维拉佐酮
参考文献: A Process For Preparation Of 2-Benzofurancarboxamide,5-[4-[4-(5Cyano-1H-Indol-3-yl)Butyl]-1-Piperazinyl] Free Base And Its Hydrochloride Salt[fr] Procédé De Préparation De La Base Libre 2-Benzofurancarboxamide,5-[4-[4-(5-Cyano-1H-Indol-3-yl)Butyl]-1-Pipérazinyle],Et De Son Sel Chlorhydrate
标题: A Process For Preparation Of 2-Benzofurancarboxamide,5-[4-[4-(5Cyano-1H-Indol-3-yl)Butyl]-1-Piperazinyl] Free Base And Its Hydrochloride Salt[fr] Procédé De Préparation De La Base Libre 2-Benzofurancarboxamide,5-[4-[4-(5-Cyano-1H-Indol-3-yl)Butyl]-1-Pipérazinyle],Et De Son Sel Chlorhydrate
摘要:本发明描述了一种有利的,经济可行的制备5-[4-[4-(5-氰基吲哚-3-基)丁基]哌嗪-1-基]苯并呋喃-2-羧酰胺自由基(式-I)及其盐酸盐的过程.本发明还描述了制备2-苯并呋喃羧酰胺,5-[4-[4-(5-氰基-1H-吲哚-3-基)丁基]-1-哌嗪基]中间体的过程.

专利信息

专利号:US-12006301-B1
优先权日:2021-05-13
标题 :And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
发明人：ABLORDEPPEY SETH Y
权利人:FLORIDA A&M UNIV
摘要:Novel dual 5-HT1A and 5-HT7 receptor ligands and methods of using the novel ligands to treat a neurological disorder are presented.

专利号:WO-2005105153-A1
优先权日:2004-04-30
标 题 :Hydroxyalkyl derivatives of biologically active compounds
发明人：DESHPANDE JAYANT VENKATESH; KADAM VAISHALI MADHUKAR; GUPTE VANDANA SANDEEP; RANBHAN KAMLESH JAYANTILAL
权利人:KOPRAN RES LAB LTD; DESHPANDE JAYANT VENKATESH; KADAM VAISHALI MADHUKAR; GUPTE VANDANA SANDEEP; RANBHAN KAMLESH JAYANTILAL
摘要:Hydroxyalkyl derivatives of biologically active compounds represented by the formula VII wherein R2 = H, CI-12 alkyl, C6-12 aryl, or -OH and D = Biologically active agent having functional groups such as Formula (a) epoxy or aziridine and Z' = Formula (b) L= spacer comprising (un)substituted alkyl, hydroxyalkyl or alkoxy alkyl with the condition that the carbon chain length contains 2 to 6 carbon atoms when Z' = Formula (c) and pharmaceutically acceptable acid addition salts and enantiomers thereof Also process for the synthesis of compounds of the Formula VII and pharmaceutically acceptable acid addition salts and enantiomers thereof comprising condensation of the biologically active agents having functional groups such as Formula (d) epoxy or azifidine with substituted alkyl derivatives under alkaline conditions, at 20 - 80°C, in an organic solvent.

专利号:WO-2016170542-A1
优先权日:2015-04-23
标题:Process for preparation of vilazodone, novel intermediates thereof and novel crystalline form thereof
发明人：BHEMIREDDY SATYANARAYANA REDDY; YARAPATHI VENKAT REDDY; PAIDIMARLA V VARA PRASADA REDDY
权利人:NOSCH LABS PRIVATE LTD
摘要:The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone. The invention also relates to novel crystalline form of Vilazodone hydrochloride and process for preparation thereof.

专利号:US-2014275542-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor
发明人：TADDEI MAURIZIO; GIANNOTTI LUCA; ATTOLINO EMANUELE; ALLEGRINI PIETRO
权利人:DIPHARMA FRANCIS SRL
摘要:Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.

专利号:US-5977112-A
优先权日:1995-04-20
标 题:Process of making substituted benzofurans
发明人：BATHE ANDREAS; HELFERT BERND; BOTTCHER HENNING; SCHUSTER KURT
权利人:MERCK PATENT GMBH
摘要:Benzofurans of the formula I ##STR1## and their salts in which R 1 , R 2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

专利号:WO-2016142952-A1
优先权日:2015-03-10
标 题:Process for preparation of vilazodone and its novel intermediates
发明人：BHEMIREDDY SATYANARAYANA REDDY; YARAPATHI VENKAT REDDY; PAIDIMARLA V VARA PRASADA REDDY
权利人:NOSCH LABS PRIVATE LTD
摘要:The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone.