专利号:US-2010075297-A1 优先权日:2006-12-20 标题 :Photosensitive polypeptide and methods of their production and use 发明人:LAWRENCE DAVID S 权利人:LAWRENCE DAVID S 摘要:Methods for producing polypeptides caged with a photolabile group on one or more backbone nitrogens are provided, in which the photolabile group is added to a growing polypeptide chain during polypeptide synthesis. Photosensitive polypeptides produced by the methods are described, as are methods of using such photosensitive polypeptides to assay enzyme activity or inhibit protein-protein interactions. Methods for producing polypeptides caged with a photolabile group on one or more side chain nitrogens, where the photolabile group is incorporated into the side chain during polypeptide synthesis, are also provided.
专利号:US-8927569-B2 优先权日:2007-07-19 标 题 :Macrocyclic compounds as antiviral agents 发明人:HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T 权利人:HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T; MERCK SHARP & DOHME 摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
专利号:WO-2004052875-A1 优先权日:2002-12-05 标 题:Tyrostatin and related anticancer drugs 发明人:PETTIT GEORGE R; ANDERSON COLLIN R 权利人:UNIV ARIZONA STATE; PETTIT GEORGE R; ANDERSON COLLIN R 摘要:The present invention relates to novel compounds having antineoplastic activity, and methods for their synthesis. The compounds are of the formula (I) wherein R is selected from the group consisting of NH2, NH3Cl, NH-Cys, NH-Gly, NH-Phe, NH-Ser, NH-Trp, NH-Tyr, and NH-Val, and pharmaceutically acceptable salts thereof.