CAS: 24994-04-5; 5-(P-Tolyl)-1H-Tetrazole

该化合物是有机化合物,其特点是四甲环,这是一个五人组成的环环,内含四氮原子和一个碳原子.该化合物具有四氯环的副甲基苯基组,具有独特的化学特性.它一般是白色的,是非白色的固体,溶于各种有机溶剂,在不同化学应用中有用.四甲苯会传播显著的生物活动,经常在制药研究中制造这种化合物.此外,苯环上的甲基组可以影响该化合物的再活动及其与生物目标的相互作用.

英文名称5-(P-Tolyl)-1H-Tetrazole
中文名称5-(对甲苯基)-1H-四氮唑
IUPAC名称5-(p-tolyl)-1H-tetrazole
其它别名5-对甲苯基四氮唑; 5-P-Tolyl-1H-Tetrazole
CAS编号24994-04-5
MFCD编号:MFCD01318164
EINECS号:607-480-6
分子式:C8H8N4
分子量:160.18
产品CID: 1203942
产品分类有机原料→分子砌块→芳杂环类化合物→四唑类化合物

相似结构搜索
InChIKey: BCCJIAZPYBJASR-UHFFFAOYSA-N
InChI=1S/C8H8N4/c1-6-2-4-7(5-3-6)8-9-11-12-10-8/h2-5H,1H3,(H,9,10,11,12)…
计算化学: 氢键受体数3.0氢键供体数1可旋转键数1

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别5(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H303 |May be 吞咽有害
防范说明P210-P240-P241-P264-P280-P302+P352-P362+P364-P370+P378
危险等级4.1
UN编号1325.0
危险品标志Xi
包装等级Ⅲ
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

Bis-(α-Amino-4-Methyl-Benzylidene)-Hydrazine置于溶剂黄146,Sodium Nitrite体系中,化学反应生成5-对甲苯基-1H-四氮唑
参考文献:Pinner,Justus Liebigs Annalen Der Chemie,1897,Vol. 298,P. 30
标题:Pinner,Justus Liebigs Annalen Der Chemie,1897,Vol. 298,P. 30

海关参考信息

2902300000-甲苯
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9724673-B2
优先权日:2011-06-30
标题:Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles
发明人：LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE
权利人:LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE; UNIV NANTES; CENTRE NAT RECH SCIENT
摘要:A supported alkoxylated organotin reactant, to the process for preparing same, to the use of such a reactant as a catalyst for heterogeneous-phase organic synthesis, and also to a process for heterogeneous-phase synthesis of 5-substituted or 1,5-disubstituted tetrazoles using such a reactant.

专利号:US-2013225819-A1
优先权日:2010-08-18
标题:Use of azides in synthesis
发明人：JAMISON TIMOTHY F; PALDE PRAKASH B
权利人:JAMISON TIMOTHY F; PALDE PRAKASH B; MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of tetrazoles. In some embodiments, the method involves the use of a flow reactor. The methods provided herein are capable at being carried out in short reaction times, with high yields, with minimal side reactions, and/or with minimal chance of explosions caused by the presence of azides.

专利号:US-2014206825-A1
优先权日:2011-06-30
标题:Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles

专利号:EP-2726515-B1
优先权日:2011-06-30
标题 :Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles

专利号:WO-2013001235-A1
优先权日:2011-06-30
标题 :Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles

专利号:EP-2726515-A1
优先权日:2011-06-30
标题:Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles