CAS: 2612-02-4; 2-Hydroxy-5-Methoxybenzoic Acid

该化合物是一种有机化合物,属于盐酸类别,其特点是苯环上存在一种氢氧基化合物和一种碳球酸组,这种特定化合物在盐酸结构的5位置上具有甲氧基化合物组(-OCH3),该物质组影响其化学特性和生物活动.它通常是一种白色的脱白晶状固体,在有机溶剂中溶解,并且水中的溶液有限. 5-甲基二氧硅酸因其潜在的反炎特性和厌食特性而闻名.此外,它也可以作为各种化学化合物合成的中间体.它的稳定性和再活性可能受到诸如pH和温度等因素的影响,而且它可能受到与箱状酸和苯丙化合物有关的典型反应.正如许多有机化合物一样,应该参考安全数据,以便处理和使用.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号586-38-9 3-甲氧基苯甲酸 | CAS号2785-98-0 2,5-二甲氧基苯甲酸 | CAS号124-38-9 二氧化碳 | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号22921-68-2 2-溴-5-甲氧基苯甲酸 | CAS号6280-89-3 2-氯-5-甲氧基苯甲 酸 | CAS号298-14-6 碳酸氢钾 | CAS号56-23-5 四氯化碳 | CAS号1200-06-2 4-甲氧基苯乙酸 | CAS号150-19-6 3-甲氧基苯酚 | CAS号490-79-9 2,5-二羟基苯甲酸 | CAS号15000-00-7 2-(2-羟基丙烷-2-基)-... | CAS号50343-02-7 3-溴-2-羟基-5-甲氧基苯甲醛 | CAS号835-64-3 2-(2-羟苯基)苯并恶唑 | CAS号672-13-9 2-羟基-5-甲氧基苯甲醛 | CAS号2905-82-0 5-甲氧基水杨酸甲酯 | CAS号3410-94-4 4-methoxy-2,6-d... | CAS号30612-17-0 6-(3H-1,3-benzo... | CAS号345924-12-1 methyl 5-methox...

合成工艺路线路线简述

    3-甲氧基苯甲酸置于氧气,Potassium Acetate,Palladium Diacetate,对苯醌体系中,用 N,N-二甲基乙酰胺 用作溶剂,化学反应 15.0H,反应生成5-甲氧基水杨酸
    参考文献:通过钯催化的 C-H 官能化和苯甲酸的原脱羧合成对位取代芳烃的通用方法
    标题:通过钯催化的 C-H 官能化和苯甲酸的原脱羧合成对位取代芳烃的通用方法
    摘要:虽然已经开发了大量的邻位 C-H 官能化反应,并在间位 C-H 活化方面取得了一些突破,但对位 C-H 官能化仍处于起步阶段.在本文中,通过由钯催化的 C-H 官能化和随后的铜催化苯甲酸原脱羧组成的串联工艺开发了一种合成对位取代芳烃的通用策略.吸电子和给电子官能团都可以引入带有各种取代基的芳烃的对位.
    Doi:10.1055/s-0035-1560579

    海关参考信息

    专利信息


    专利号:WO-2004011474-A1
    优先权日:2002-07-31
    标题:Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6653468-B1
    优先权日:2002-07-31
    标 题 :Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-10005720-B2
    优先权日:2013-04-05
    标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
    发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
    权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
    摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

    专利号:US-6180830-B1
    优先权日:1995-11-08
    标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
    发明人:JACQUOT ROLAND
    权利人:RHODIA CHIMIE SA
    摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:A Catalyst-Free, Facile And Efficient Approach To Cyclic Esters: Synthesis Of 4H-Benzo[d][1,3]Dioxin-4-Ones
    作者:Feng Lin,Qiuling Song,Yuyu Gao,Xiuling Cui
    摘要:A Metal And Additive Free Base-Mediated Method For The Formation Of 4H-Benzo[d][1,3]Dioxin-4-One And Its Derivatives, From Salicylic Acids And Dichloromethane, Was Developed Using Dichloromethane (Dcm) And 1,1-Dichloroethane (1,1-Dce) As The C1 Source.

    合成参考文献


    摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 215.
    摘要:Hitomi, Y.; Arakawa, K., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 297.
    摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 355.
    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf
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