专利号:US-4338466-A 优先权日:1981-04-02 标 题 :Prostaglandin analogs and process of preparation thereof 发明人:NELSON GEORGE L 权利人:US NAVY 摘要:Prostaglandin analogs and process for the preparation thereof as precursors for the synthesis of oligomeric mixtures exhibiting biological activity for protection of oxidative phosphorylation of degraded mitochondria. The analogs have the general formula: synthesized by O-alkylating a 2-alkylcyclopentane-1,3-dione to form an enol ether, reacting the ether with CH2=CHMgBr to form a vinyl, oxidizing the vinyl with OsO4 and NaIO4 to form an aldehyde, and reacting the aldehyde with a sodium salt of dimethyl (2-oxoalkyl)phosphonate.
专利号:WO-2022170218-A1 优先权日:2021-02-05 标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates 发明人:QIN TIAN; YANG YANGYANG; TSIEN JET 权利人:UNIV TEXAS 摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.
专利号:US-7598403-B2 优先权日:2003-05-16 标 题 :Synthesis of chromanones 发明人:SALVATORE BRIAN A; SOLIS FERDINAND C 权利人:UNIV SOUTH CAROLINA RES FOUND 摘要:Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be useful for a variety of therapies, including the treatment of various cancers and the treatment of inflammation and inflammation related disorders.
专利号:US-6552239-B1 优先权日:1999-10-28 标题:Synthesis of cyclopropaneacetylene by a one-pot process 发明人:BRANDS KAREL M J 权利人:MERCK & CO INC 摘要:The present invention relates to a process for the preparation of cyclopropaneacetylene by reacting a ketophosphonate with a diazo-transfer reagent in the presence of non-nucleophilic base in an aprotic solvent to generate a reaction mixture containing a ketodiazophosphonate compound and then reacting the reaction mixture with cyclopropanecarboxaldehyde in a non-nucleophilic base and a protic solvent to yield cyclopropaneacetylene.
专利号:US-6297194-B1 优先权日:1999-02-02 标 题 :Production of phosphonopyrazoles 发明人:MILLER PAULA C; CURTIS JANE M; MOLYNEAUX JOHN M; OWEN THOMAS J 权利人:MONSANTO TECHNOLOGY LLC 摘要:Pyrazole compounds with activity as chemical hybridizing agents and methods for synthesis of such compounds are disclosed. These compounds are useful in producing hybrid wheat (Triticum aesativum) and other crops.
专利号:US-2002107401-A1 优先权日:2000-02-02 标题:Production of phosphonopyrazoles 发明人:MILLER PAULA C; CURTIS JANE M; MOLYNEAUX JOHN M; OWEN THOMAS J 权利人:MONSNTO TECHNOLOGY LLC 摘要:Novel compounds with activity as chemical hybridizing agents and methods for synthesis of such compounds are disclosed. These compounds are useful in producing hybrid wheat ( Triticum aesativum ) and other crops.
参考标题:Convergent Synthesis Of Kibdelone C 作者:Yihua Dai,Feixia Ma,Yanfang Shen,Tao Xie,Shuanhu Gao |发布日期:2018.5.18 摘要:The Synthesis Of Kibdelone C, A Polycyclic Natural Xanthone Isolated From A Soil Actinomycete, Was Achieved Through A Convergent Approach. A 6π-Electrocyclization Was Applied To Construct The Highly Substituted Dihydrophenanthrenol Fragment (B-C-D Ring). Inbr3-Promoted Lactonization Was Employed To Build The Isocoumarin Ring, Which Served As A Common Precursor For The Formation Of Isoquinolinone Ring
合成参考文献
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