CAS: 507-40-4; Tert-Butyl Hypochlorite

上下游产品

叔丁醇 Tert-Butyl Alcohol 75-65-0

叔丁醇置于sodium Hypochlorite,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 0.05H,以52%的收率获得产物次氯酸叔丁酯
参考文献:源自grundmann酮的细胞毒性环a修饰的类固醇类似物
标题:源自grundmann酮的细胞毒性环a修饰的类固醇类似物
摘要:合成了一系列包含具有各种功能的六元环a的类固醇和氮杂类固醇类似物.此外,进行了带有五元a环的四环类似物的合成以及许多双环类固醇类固醇类似物的合成.测试所有化合物的抗菌,抗真菌和细胞毒性活性.在所有测试的化合物中,7和9表现出杰出的细胞毒性活性,但没有抗微生物活性.化合物的细胞毒性活性7,9和10最初是由美国国家癌症研究所(nci)在单剂量60细胞试验验证.根据我们的结果7和9 满足了进行5剂量nci筛选的预定阈值抑制标准,该标准揭示了这两种候选药物的选择性活性谱.
DOI:10.1016/j.Ejmech.2011.04.036

专利信息

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:WO-2024105700-A1
优先权日:2022-11-18
标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).

专利号:WO-2025134140-A1
优先权日:2023-12-19
标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; SHAH JIGARKUMAR HARKISHANDAS; KALE MANOJ GANPAT; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein, R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2-C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The method further comprises the synthesis of an anthranilic diamide compound of formula (A).

专利号:WO-2025057193-A1
优先权日:2023-09-13
标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; KALE MANOJ GANPAT; SHAH JIGARKUMAR HARKISHANDAS; GAVHANE KISHOR BAPU; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention provides a method for the synthesis of compounds of formula (I), intermediates, and salts thereof, formula (I) wherein, R, R1 and n are as described in the description. The method further comprises the synthesis of anthranilic diamide compounds of formula (E), wherein the formula (E) is described in the description.

专利号:US-4431828-A
优先权日:1982-11-10
标题 :Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
发明人：CUE JR BERKELEY W; HAMMEN PHILIP D; MASSETT STEPHEN S
权利人:PFIZER
摘要:6-Fluoro-4-chromanone, a sorbinil intermediate, is regenerated from enantiomeric and mixtures of enantiomeric and racemic compounds obtained as major by-products in the synthesis of sorbinil. The regenerated intermediate is useful in the synthesis of additional sorbinil.

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.