专利号:US-2024059701-A1 优先权日:2021-04-22 标 题 :Methods for Synthesis of an Advantageous N-Heterocyclic Carbene Catalyst 发明人:CAHANA AVIAD; FARONE WILLIAM A 权利人:XF TECH INC 摘要:The present invention concerns the synthesis of the salts of a Triazolium N-Heterocyclic Carbene (NHC) catalyst in various salt forms prepared from 2-methylaniline, 2-methylphenylhydrazine hydrochloride or 2-methylphenylhydrazine. The molecules so prepared are useful in catalysis of carbene reactions and are advantageous due to their lack of chlorinated or fluorinated intermediates and lack of chlorine or fluorine in the final structure.
专利号:US-8629288-B2 优先权日:2008-02-25 标题:Method for the regioselective synthesis of 1-alky1-3-haloalkyl-pyrazole-4-carboxylic acid derivatives 发明人:PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS 权利人:PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS; BAYER IP GMBH 摘要:The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.
专利号:US-6906046-B2 优先权日:2000-12-22 标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes 发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY 权利人:CELLTECH R & D INC 摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.
专利号:US-8212056-B2 优先权日:2008-06-30 标 题 :Ligands for transition-metals and methods of use 发明人:KWONG FUK YEE; SO CHAU MING 权利人:KWONG FUK YEE; SO CHAU MING; UNIV HONG KONG POLYTECHNIC 摘要:The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.
专利号:US-9469603-B2 优先权日:2012-03-12 标 题 :Reaction product of hydrazine derivatives and carbon dioxide 发明人:HUR NAM HWI; LEE BYEONG NO 权利人:UNIV SOGANG RES FOUNDATION 摘要:The present invention relates to the synthesis of a novel compound, in which liquid hydrazine and the derivatives thereof react with excess carbon dioxide to enable the carbon dioxide to chemically bond to the hydrazine and the derivatives thereof. To this end, high-pressure carbon dioxide is used to synthesize hydrazine and the derivatives thereof to which the carbon dioxide is bonded in a pure form with no water and no by-product. Furthermore, the present invention provides a method for utilizing the above-described compounds by reacting the compounds with carbonyl compounds.
专利号:US-7323483-B2 优先权日:2005-01-27 标题:Processes and compounds for the preparation of substituted naphthylindole derivatives 发明人:DRAGAN VLADIMIR A; POTOSKI JOHN RICHARD; MCMAHON WAYNE G; HELOM JEAN LOUISE; SHI XINXU 权利人:WYETH CORP 摘要:The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
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